STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0116Hypothetical protein; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (228 aa)    
Predicted Functional Partners:
Ta0285
3-dehyroquinate synthase related protein; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
  
 
 0.958
Ta0284
Shikimate 5-dehydrogenase related protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
    
 0.943
Ta0282
3-phosphoshikimate 1-carboxyvinyltransferase related protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
  
 0.793
Ta0824
Probable chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
  
 0.731
Ta0247
Strong similarity to known protein: Synechocystis sp. ccmA gene for 32.4kD protein and ORF271 for 29.5kDprotein, complete cds; TREMBL:SSCCMA_1.
  
  
 0.678
Ta0117
Strong similarity to known protein: isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) - Bacillus subtilis; PIR:I40382.
     
 0.631
Ta0363
Similarity to known protein: Ustilgo maydis aspartate semialdehyde dehydrogenase (ASADH) mRNA, completecds; TREMBL:UM44901_1.
  
 
 0.576
Ta0364
Similarity to known protein: A.thaliana mRNA for aspartate kinase; TREMBL:ATAKLYS1_1.
  
 
 0.523
Ta0283
Conserved hypothetical protein; Similarity to unknown protein: homoserine kinase PAB0301 - Pyrococcus abyssi (strain Orsay); PIR:F75161.
     
 0.518
Ta0808
Similarity to known protein: indole-3-glycerol-phosphate synthase (EC 4.1.1.48) TrpC - Sulfolobus solfataricus; PIR:C40635; Belongs to the TrpC family.
  
 
 0.516
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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