STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0242Strong similarity to known protein: HISTIDINE AMMONIA-LYASE (EC 4.3.1.3) (HISTIDASE).HISTIDINE AMMONIA-LYASE (EC 4.3.1.3) (HISTIDASE) - Pseudomonas putida.Pseudomonas putida; SWISSPROT:HUTH_PSEPU; Belongs to the PAL/histidase family. (496 aa)    
Predicted Functional Partners:
Ta0238
Similarity to known protein: ATRAZINE CHLOROHYDROLASE (EC 3.8.1.-) - Pseudomonas sp. (strain ADP); SWISSPROT:ATZA_PSESD; Belongs to the metallo-dependent hydrolases superfamily. HutI family.
 
  
 0.999
Ta0239
Probable urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.
 
 0.999
Ta1058
Similarity to known protein: agmatinase (EC 3.5.3.11) [validated] - Escherichia coli; PIR:C42604Function: Arginine and proline metabolism; Belongs to the arginase family.
  
  
 0.877
Ta1060
Similarity to known protein: ATRAZINE CHLOROHYDROLASE (EC 3.8.1.-) - Pseudomonas sp. (strain ADP); SWISSPROT:ATZA_PSESDFunction: FIRST STEP IN ATRAZINE DEGRADATION PATHWAY.
  
  
 0.720
Ta1476
Probable glutamate formiminotransferase; Catalyzes the transfer of the formyl group from N- formylglutamate to tetrahydrofolate (THF) to yield 5- formyltetrahydrofolate (5-CHO-THF) and glutamate (Glu). The triglutamate form of 5-CHO-THF (5-CHO-THF-Glu3) can also be used as substrate. It can also catalyzes the transfer of the formimino group from N-formiminoglutamate to tetrahydrofolate (THF) to yield 5- formiminotetrahydrofolate (5-NH=CH-THF) and glutamate (Glu). It can replace YgfA to catalyzes the irreversible ATP-dependent transformation of 5-CHO-THF to form 5,10-methenyltetrahydrof [...]
  
  
 0.653
Ta1477
Similarity to known protein: Gallus gallus mRNA for formiminotransferase cyclodeaminase; TREMBL:GGA224473_1.
  
  
 0.653
Ta0243
Hypothetical protein.
       0.558
Ta1357
Glycine dehydrogenase (decarboxylating) related protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
   
  
 0.537
Ta1018
Similarity to known protein: SERINE--GLYOXYLATE AMINOTRANSFERASE (EC 2.6.1.45) (SGAT) - Hyphomicrobium methylovorum; SWISSPROT:SGAA_HYPMEFunction: L-Serine + Glyoxylate = 3-Hydroxypyruvate + Glycine Involved in glycine, serine and threonine metabolism.
  
  
 0.468
Ta0797
Similarity to unknown protein: conserved hypothetical protein - Deinococcus radiodurans (strain R1); PIR:D75292.
  
    0.462
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.