STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0858Similarity to known protein: GLYCERATE DEHYDROGENASE (EC 1.1.1.29) (NADH-DEPENDENT HYDROXYPYRUVATEREDUCTASE) (HPR) (GDH) (HYDROXYPYRUVATE DEHYDROGENASE) (GLYOXYLATEREDUCTASE) (HPR-A) - Methylobacterium extorquens; SWISSPROT:DHGY_METEX; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (303 aa)    
Predicted Functional Partners:
Ta0453
Glycerate kinase related protein; Similarity to known protein: Methylobacterium extorquens putative glycerate kinase and pyruvate kinase(pykA) genes, complete cds; TREMBLNEW:MEU87316_4.
 
 
 0.970
Ta0542
Probable D-lactate dehydrogenase; Strong similarity to known protein: glycolate oxidase subunit (glcD) homolog - Archaeoglobus fulgidus; PIR:H69350.
 
 
 0.960
Ta0175
Conserved hypothetical protein; Catalyzes the dephosphorylation of 2-phosphoglycolate. Also has significant, but less efficient, pyrophosphatase activity, since it is able to catalyze the release of phosphate from inorganic pyrophosphate (PPi); Belongs to the HAD-like hydrolase superfamily. Archaeal SPP-like hydrolase family.
  
 
 0.927
Ta0845
Hypothetical protein; Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP).
    
 0.918
Ta0460
Endonuclease V related protein; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity); In the N-terminal section; belongs to the MGMT family.
     
 0.804
Ta1018
Similarity to known protein: SERINE--GLYOXYLATE AMINOTRANSFERASE (EC 2.6.1.45) (SGAT) - Hyphomicrobium methylovorum; SWISSPROT:SGAA_HYPMEFunction: L-Serine + Glyoxylate = 3-Hydroxypyruvate + Glycine Involved in glycine, serine and threonine metabolism.
  
  
 0.726
Ta0102
Conserved hypothetical protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
 0.714
Ta0616
Probable transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
  
 
 0.662
Ta0880
Ribokinase related protein; Nucleoside kinase with broad substrate specificity. Catalyzes the phosphorylation of a variety of nucleosides to the corresponding nucleoside 5'-mono-phosphate in the presence of phosphate donors and divalent cations. Displays the most efficient activity with guanosine, followed by inosine, cytidine, and adenosine. Negligible enzymatic activity is detected with thymidine, uridine, and 2-deoxyadenosine. ATP is the most efficient phosphate donor, but can also use GTP and ITP. Shows no sugar kinase activity, since it is unable to phosphorylate ribose, fructose- [...]
 
  
 0.628
Ta0952
Probable malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
 
 0.626
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.