STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0912Probable DNA binding protein (Ssh10b related); Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. (89 aa)    
Predicted Functional Partners:
Ta1247
Probable adenylate kinase; Strong similarity to known protein: ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - Methanococcus igneus; SWISSPROT:KAD_METIG; Belongs to the archaeal adenylate kinase family.
  
     0.608
Ta0600
Similarity to unknown protein: conserved hypothetical protein MTH1407 - Methanobacterium thermoautotrophicum (strain Delta H); PIR:D69054; Belongs to the UPF0147 family.
  
     0.589
Ta1299
Strong similarity to unknown protein: hypothetical protein PH1822 - Pyrococcus horikoshii; PIR:F71193.
  
     0.581
Ta0042
Similarity to unknown protein: hypothetical protein MJ1150 - Methanococcus jannaschii; PIR:E64443; Belongs to the UPF0215 family.
 
     0.568
Ta0097
Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
     0.503
Ta0913
Conserved hypothetical protein; Weak similarity to known protein. Relation: weak similarity to PIR:A42468 (7alpha-hydroxysteroid dehydrogenase).
       0.472
Ta0036
DNA polymerase II (DP1), subunit 2 related protein; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
  
     0.470
Ta1035
DNA repair protein RAD2 related protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision rep [...]
  
     0.459
Ta1380
Conserved hypothetical protein; Involved in DNA damage repair.
  
     0.444
Ta1441
Conserved hypothetical protein; Similarity to unknown protein: probable 3-isopropylmalate dehydratase - Archaeoglobus fulgidus; PIR:B69406.
  
    0.444
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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