STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0093DNA-binding protein HTa; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. (90 aa)    
Predicted Functional Partners:
Ta1131
Strong similarity to known protein: 40s ribosomal protein s13 - fission yeast (Schizosaccharomyces pombe); PIR:S26296.
  
  
 0.686
Ta0915
Chorismate mutase/prephenate dehydratase related protein; Similarity to known protein: Pseudomonas stutzeri gyrase A subunit (gyrA) gene, partial cds;3-phosphoserine aminotransferase (serC), chorismate mutase/prephenatedehydratase (aroQp/pheA), imidazole acetol phosphate aminotransferase(hisHb), and cyclohexadienyl dehydrogenase (tyrAc) genes, complete cds; and5-enolpyruvylshikmate 3-P synthase (aroF) gene, partial cds; TREMBL:AF038578_3.
     
 0.674
Ta0460
Endonuclease V related protein; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity); In the N-terminal section; belongs to the MGMT family.
  
 
 0.661
Ta0063
DNA topoisomerase III beta related protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, [...]
  
  
 0.582
Ta0245
Conserved hypothetical protein; Similarity to unknown protein: chorismate mutase (EC 5.4.99.5) chain A - Methanococcus jannaschii; PIR:G64330.
     
 0.582
Ta0097
Conserved hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
     
 0.571
Ta0073
Orotidine-5'-monophosphate decarboxylase (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
     
 0.569
Ta0805
Weak similarity to known protein. Relation: weak similarity to phosphoribosylanthranilate isomerase - Aquifex aeolicus, PIR:A70478; Belongs to the TrpF family.
     
 0.550
Ta0282
3-phosphoshikimate 1-carboxyvinyltransferase related protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
     
 0.547
Ta1059
Translation initiation factor eIF-5a related protein; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
  
  
 0.533
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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