STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0187Weak similarity to known protein. Relation: weak similarity to divalent cation tolerance protein cutA1, E. coli, PIR2:I41027. (54 aa)    
Predicted Functional Partners:
Ta0805
Weak similarity to known protein. Relation: weak similarity to phosphoribosylanthranilate isomerase - Aquifex aeolicus, PIR:A70478; Belongs to the TrpF family.
     
 0.543
Ta0042
Similarity to unknown protein: hypothetical protein MJ1150 - Methanococcus jannaschii; PIR:E64443; Belongs to the UPF0215 family.
       0.426
Ta0064
Similarity to known protein: acylphosphatase (EC 3.6.1.7) Ch2, skeletal muscle - chicken; PIR:QPCH2Function: Glycolysis / Gluconeogenesis, Phenylalanine metabolism, Pyruvate metabolism.
       0.426
Ta0622
Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
       0.426
Ta0803
Similarity to known protein: TRYPTOPHAN SYNTHASE ALPHA CHAIN (EC 4.2.1.20).TRYPTOPHAN SYNTHASE ALPHA CHAIN (EC 4.2.1.20) - Sulfolobus solfataricus.Sulfolobus solfataricus; SWISSPROT:TRPA_SULSO.
       0.426
Ta0899
NAD(+) synthase related protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
       0.426
Ta1000
DNA helicase II (UvrD) related protein; Similarity to known protein: ATP-DEPENDENT HELICASE PCRA (EC 3.6.1.-).ATP-DEPENDENT DNA HELICASE PCRA (EC 3.6.1.-) - Bacillus stearothermophilus.Bacillus stearothermophilus; SWISSPROT:PCRA_BACSTORF_prediction: C-terminus around 200 aa longer than the other DNA helicases.
       0.426
Ta1274
Similarity to known protein: STEROL-REGULATORY ELEMENT-BINDING PROTEINS INTRAMEMBRANE PROTEASE(EC 3.4.24.-) (SITE-2 PROTEASE) - Homo sapiens (Human); SWISSPROT:MS2P_HUMANFunction: similar to S2P, that encodes a putative metalloprotease required for intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) at Site-2. SREBPs are membrane-bound transcription factors that activate genes regulating cholesterol metabolism. The active NH2-terminal domains of SREBPs are released from membranes by sequential cleavage at two sites: Site-1, within the lumen of the endoplasm [...]
       0.426
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.