STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0522Probable pyridoxine biosynthesis pyroA protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (336 aa)    
Predicted Functional Partners:
Ta0009
Hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
 0.999
Ta0616
Probable transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
    
 0.887
Ta0520
Similarity to unknown protein: conserved hypothetical protein AF0706 - Archaeoglobus fulgidus; PIR:B69338.
       0.818
Ta0618
Probable transketolase; Strong similarity to known protein: TRANSKETOLASE (EC 2.2.1.1) (TK) (P68) - Mus musculus (Mouse); SWISSPROT:TKT_MOUSE.
    
  0.817
Ta0617
Probable transketolase; Strong similarity to known protein: TRANSKETOLASE (EC 2.2.1.1) (TK) (P68) - Mus musculus (Mouse); SWISSPROT:TKT_MOUSE.
    
  0.816
Ta0119
RIBOSE-PHOSPHATE PYROPHOSPHOKINASE related protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
  
 
  0.813
Ta0878
Ribose-5-phosphate isomerase related protein; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
    
  0.801
Ta0568
Similarity to known protein: phosphomannomutase (pmm) homolog - Archaeoglobus fulgidus; PIR:B69307; Belongs to the phosphohexose mutase family.
     
  0.800
Ta0026
Similarity to known protein: threonine synthase (EC 4.2.99.2) thrC - Bacillus subtilis; PIR2:A25364Function: Glycine, serine and threonine metabolism.
  
  
 0.666
Ta0495
Similarity to known protein: threonine synthase (EC 4.2.99.2) thrC - Bacillus subtilis; PIR:A25364.
  
  
 0.620
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.