STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0551Similarity to known protein: PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN CYTOPLASMIC (EC 6.1.1.20)(PHENYLALANINE--TRNA LIGASE ALPHA CHAIN) (PHERS) - Candida albicans (Yeast); SWISSPROT:SYFA_CANAL. (543 aa)    
Predicted Functional Partners:
Ta0639
Similarity to known protein: phenylalanine--tRNA ligase (EC 6.1.1.20) beta chain, cytosolic [validated] - yeast (Saccharomyces cerevisiae); PIR:YFBYAC; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
 
 0.999
Ta0777
Similarity to known protein: leucyl-tRNA synthetase (leuS) homolog - Archaeoglobus fulgidus; PIR:F69552; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.983
Ta0879
isoleucyl-tRNA synthetase related protein; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
 
 0.962
Ta0330
threonine--tRNA ligase related protein; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).
 
 
 0.885
Ta1190
Strong similarity to known protein: ribosomal protein S2 [validated] - Haloarcula marismortui; PIR:G41715; Belongs to the universal ribosomal protein uS2 family.
 
 
 0.885
Ta0281
Similarity to known protein: arginine--tRNA ligase (EC 6.1.1.19) - Corynebacterium glutamicum; PIR1:A49936; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
  
 0.878
Ta1265
Probable 30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.
  
 
 0.871
Ta0512
Probable tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
  
  
 0.863
Ta1267
Probable 30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
  
 
 0.860
Ta0506
Thiazole biosynthesis protein Thi I related protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.841
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
Server load: low (6%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.