STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta0603Similarity to known protein: aldehyde dehydrogenase (EC 1.2.-.-) - Bacillus stearothermophilus; PIR:I39769. (515 aa)    
Predicted Functional Partners:
Ta0529
Probable aspartate aminotransferase; Strong similarity to known protein: aspartate transaminase (EC 2.6.1.1) - Sulfolobus solfataricus; PIR:S07088Function: Glutamate metabolism, Alanine and Aspartate metabolism Cysteine metabolism, Carbon fixation.
  
 0.931
Ta0635
Strong similarity to known protein: GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - Thermococcus litoralis; SWISSPROT:DHE3_THELIFunction: generally involved with either ammonia assimilation or glutamate catabolism. ORF_prediction: N-terminus longer than those of trelated proteins, however its codon usage does support a coding function of the first 40 aa, the frequency of rare codons is very low, possible second start only after 35 aa, not altered; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.931
Ta0776
Strong similarity to known protein: GLUTAMATE DEHYDROGENASE (EC 1.4.1.3) (GDH) - Pyrococcus horikoshii; SWISSPROT:DHE3_PYRHO; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.931
Ta0414
Similarity to known protein: GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN (EC 1.4.1.13) (GLUTAMATESYNTHASE BETA SUBUNIT) (NADPH-GOGAT) (GLTS BETA CHAIN) - Escherichia coli; SWISSPROT:GLTD_ECOLI.
   
 0.927
Ta1498
Probable glutamine synthetase; Strong similarity to known protein: Bacillus subtilis glnR and glnA genes for GlnR protein and glutaminesynthetase, complete cds; TREMBL:BSGLNRA_2.
 
 
 0.926
Ta0139
Pyrroline-5-carboxylate reductase related protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
 
 0.924
Ta1318
Phosphoribosylformylglycinamidine synthase I related protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is tho [...]
    
  0.903
Ta0010
Strong similarity to known protein: aminomethyltransferase (EC 2.1.2.10) [validated] - Escherichia coli; PIR:A56689Function: Glycine, serine and threonine metabolism, One carbon pool by folate, Nitrogen metabolism.
  
 
 0.866
Ta1366
Probable glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 
 0.839
Ta1357
Glycine dehydrogenase (decarboxylating) related protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
  
 
 0.836
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.