STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta1018Similarity to known protein: SERINE--GLYOXYLATE AMINOTRANSFERASE (EC 2.6.1.45) (SGAT) - Hyphomicrobium methylovorum; SWISSPROT:SGAA_HYPMEFunction: L-Serine + Glyoxylate = 3-Hydroxypyruvate + Glycine Involved in glycine, serine and threonine metabolism. (382 aa)    
Predicted Functional Partners:
Ta0779
Similarity to unknown protein: 2-hydroxyacid dehydrogenase homolog - Archaeoglobus fulgidus; PIR:B69472. Relation: SIM. to PIR:A47117 formate dehydrogenase (EC 1.2.1.2) - Neurospora crassa and to SERA_ARATH phosphoglycerate dehydrogenase (EC 1.1.1.95) - A.taliana, the function is not clear.
  
  
 0.884
Ta1227
Probable carboxyphosphonoenolpyruvate phosphonomutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
  
  
 0.785
Ta1019
MoaD (involved in molybdopterin synthesis) related protein; Similarity to known protein: Mus musculus molybdopterin-synthase small and large subunit (Mocs2)bicistronic mRNA, complete cds; TREMBL:AF091872_1.
       0.774
Ta0068
Similarity to known protein: Acinetobacter baumannii DNA for L-2, 4-diaminobutyrate:2-ketoglutarate4-aminotransferase, complete cds; TREMBL:AB001599_1Function: Glutamate metabolism, Alanine and Aspartate metabolism, beta-Alanine metabolism, Propanoate metabolism, Butanoate metabolism; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.767
Ta0858
Similarity to known protein: GLYCERATE DEHYDROGENASE (EC 1.1.1.29) (NADH-DEPENDENT HYDROXYPYRUVATEREDUCTASE) (HPR) (GDH) (HYDROXYPYRUVATE DEHYDROGENASE) (GLYOXYLATEREDUCTASE) (HPR-A) - Methylobacterium extorquens; SWISSPROT:DHGY_METEX; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
  
 0.726
Ta0882
Enolase related protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
  
 0.702
Ta0849
alanyl-tRNA synthetase related protein; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
  
 0.688
Ta0102
Conserved hypothetical protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 0.686
Ta1139
Aut related protein; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
  
  
 0.686
Ta0845
Hypothetical protein; Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP).
     
 0.674
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.