STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta1436Probable lipoamide acyltransferase; Strong similarity to known protein: Myxococcus xanthus lipoic acid synthetase precursor, lipoamideacyltransferase, and lipoate-protein ligase B genes, complete cds; andunknown genes; TREMBL:AF153678_2. (400 aa)    
Predicted Functional Partners:
Ta0208
Similarity to known protein: dihydrolipoamide dehydrogenase (EC 1.8.1.4) - Escherichia coli; PIR:DEECLP.
 0.999
Ta1435
Similarity to known protein: dihydrolipoamide dehydrogenase (EC 1.8.1.4) - Bacillus subtilis; PIR:E36718.
 0.999
Ta1437
Strong similarity to known protein: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4) chain E1-beta - Pseudomonas putida; PIR:DEPSEB.
 0.999
Ta1438
Strong similarity to known protein: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4) alpha chain precursor - human; PIR:DEHUXAORF_prediction: The N-terminus of this protein is short by 60aa compared to other proteins, sequence analysis clearly rules out an elongated N-terminus.
 0.999
Ta1332
Probable succinyl-CoA synthetase, beta subunit; Strong similarity to known protein: succinate--CoA ligase (ADP-forming) (EC 6.2.1.5) beta chain [validated] - Thermus aquaticus; PIR:S15950.
 
 0.998
Ta1331
Probable succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.997
Ta1366
Probable glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 0.987
Ta1341
Similarity to known protein: mercury(II) reductase (EC 1.16.1.1) - Staphylococcus aureus plasmid pI258; PIR:E29504; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 0.984
Ta0169
Known protein: citrate (si)-synthase (EC 4.1.3.7) - Thermoplasma acidophilum; PIR:YKYT.
  
 0.979
Ta0819
Probable citrate (si)-synthase; Strong similarity to known protein: CITRATE SYNTHASE (EC 4.1.3.7) - Thermoplasma acidophilum; SWISSPROT:CISY_THEAC.
  
 0.979
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.