STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ta1475Ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase class-2 family. (770 aa)    
Predicted Functional Partners:
Ta0081
Conserved hypothetical protein; Similarity to unknown protein: thymidylate kinase (tmk) homolog - Archaeoglobus fulgidus; PIR:E69257.
  
 
 0.958
Ta0917
Proliferating cell nuclear antigen (PCNA) related protein; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 
 0.956
Ta0799
DNA replication licensing factor MCM related protein; Similarity to known protein: CDC21 PROTEIN.CDC21 PROTEIN - Schizosaccharomyces pombe (Fission yeast).Schizosaccharomyces pombe (Fission yeast); SWISSPROT:CC21_SCHPO; Belongs to the MCM family.
  
  
 0.953
Ta1113
Probable nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
 0.932
Ta1247
Probable adenylate kinase; Strong similarity to known protein: ADENYLATE KINASE (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE) - Methanococcus igneus; SWISSPROT:KAD_METIG; Belongs to the archaeal adenylate kinase family.
  
  
  0.915
Ta0896
Similarity to known protein: pyruvate kinase (EC 2.7.1.40) [validated] - Bacillus licheniformis; PIR:JC4220.
    
 0.913
Ta0570
Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
   
 
  0.907
Ta1245
Probable cytidylate kinase; Strong similarity to known protein: CYTIDYLATE KINASE (EC 2.7.4.14) (CK) (CYTIDINE MONOPHOSPHATE KINASE)(CMP KINASE).CYTIDYLATE KINASE (EC 2.7.4.14) (CK) (CYTIDINE MONOPHOSPHATE KINASE)(CMP KINASE) - Sulfolobus acidocaldarius.Sulfolobus acidocaldarius; SWISSPROT:KCY_SULAC.
    
  0.905
Ta0998
Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
     
  0.900
Ta1121
Similarity to known protein: COB(I)ALAMIN ADENOSYLTRANSFERASE (EC 2.5.1.17) (CORRINOIDADENOSYLTRANSFERASE) - Pseudomonas denitrificans; SWISSPROT:COBO_PSEDE.
     
 0.868
Your Current Organism:
Thermoplasma acidophilum
NCBI taxonomy Id: 273075
Other names: T. acidophilum DSM 1728, Thermoplasma acidophilum DSM 1728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.