node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GRPE | WS1254 | WS0495 | WS1254 | GRPE PROTEIN (HSP-70 COFACTOR); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | PUTATIVE TRANSCRIPTIONAL REGULATOR. | 0.531 |
GRPE | WS1498 | WS0495 | WS1498 | GRPE PROTEIN (HSP-70 COFACTOR); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | Hypothetical protein. | 0.795 |
GRPE | dnaK | WS0495 | WS0494 | GRPE PROTEIN (HSP-70 COFACTOR); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | HEAT SHOCK PROTEIN, DNAK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.998 |
GRPE | htpG | WS0495 | WS1737 | GRPE PROTEIN (HSP-70 COFACTOR); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | CHAPERONE (HEAT SHOCK PROTEIN); Molecular chaperone. Has ATPase activity. | 0.843 |
GRPE | rsfS | WS0495 | WS0670 | GRPE PROTEIN (HSP-70 COFACTOR); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.476 |
RPLK | RPLM | WS0463 | WS2138 | 50S RIBOSOMAL PROTEIN L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 50S RIBOSOMAL PROTEIN L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.989 |
RPLK | RPLQ | WS0463 | WS1691 | 50S RIBOSOMAL PROTEIN L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 50S RIBOSOMAL PROTEIN L17. | 0.984 |
RPLK | WS1498 | WS0463 | WS1498 | 50S RIBOSOMAL PROTEIN L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | Hypothetical protein. | 0.709 |
RPLK | dnaK | WS0463 | WS0494 | 50S RIBOSOMAL PROTEIN L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | HEAT SHOCK PROTEIN, DNAK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.753 |
RPLK | rsfS | WS0463 | WS0670 | 50S RIBOSOMAL PROTEIN L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.845 |
RPLK | thdF | WS0463 | WS1284 | 50S RIBOSOMAL PROTEIN L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | PUTATIVE TRNA MODIFICATION GTPASE TRME; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.825 |
RPLM | RPLK | WS2138 | WS0463 | 50S RIBOSOMAL PROTEIN L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 50S RIBOSOMAL PROTEIN L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.989 |
RPLM | RPLQ | WS2138 | WS1691 | 50S RIBOSOMAL PROTEIN L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 50S RIBOSOMAL PROTEIN L17. | 0.984 |
RPLM | WS1498 | WS2138 | WS1498 | 50S RIBOSOMAL PROTEIN L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | Hypothetical protein. | 0.713 |
RPLM | dnaK | WS2138 | WS0494 | 50S RIBOSOMAL PROTEIN L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | HEAT SHOCK PROTEIN, DNAK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.812 |
RPLM | rsfS | WS2138 | WS0670 | 50S RIBOSOMAL PROTEIN L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.857 |
RPLM | thdF | WS2138 | WS1284 | 50S RIBOSOMAL PROTEIN L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | PUTATIVE TRNA MODIFICATION GTPASE TRME; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.817 |
RPLQ | RPLK | WS1691 | WS0463 | 50S RIBOSOMAL PROTEIN L17. | 50S RIBOSOMAL PROTEIN L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.984 |
RPLQ | RPLM | WS1691 | WS2138 | 50S RIBOSOMAL PROTEIN L17. | 50S RIBOSOMAL PROTEIN L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.984 |
RPLQ | WS1498 | WS1691 | WS1498 | 50S RIBOSOMAL PROTEIN L17. | Hypothetical protein. | 0.721 |