STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisS-2Hypothetical protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). (286 aa)    
Predicted Functional Partners:
hisS-3
HISTIDYL-TRNA SYNTHETASE.
     
  0.900
PURA
ADENYLOSUCCINATE SYNTHETASE IMP-ASPARTATE LIGASEADSS AMPSASE; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
  
 0.836
hisI
PUTATIVE PHOSPHOHYDROLASE; PHOSPHORIBOSYL-AMP CYCLOHYDROLASE/PHOSPHORIBOSYL-ATPPYROPHOSPHOHYDROLASE; In the C-terminal section; belongs to the PRA-PH family.
 
 
 0.823
PDP
PDP PROTEIN.
       0.816
WS2055
Hypothetical protein.
       0.816
hisG
ATP PHOSPHORIBOSYLTRANSFERASE; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
 
 0.802
ASPS
ASPARTYL-TRNA SYNTHETASE; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
  
  
 0.786
UPPS
PUTATIVE UNDECAPRENYL DIPHOSPHATE SYNTHASE; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
  
    0.694
hisB
IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE.
  
  
 0.678
DFP
PANTOTHENATE METABOLISM FLAVOPROTEIN; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
  
   0.671
Your Current Organism:
Wolinella succinogenes
NCBI taxonomy Id: 273121
Other names: W. succinogenes DSM 1740, Wolinella succinogenes DSM 1740
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