node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PAN3 | PEX2_024750 | A0A0A2K3K9 | A0A0A2JGT4 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] | Uncharacterized protein family UPF0662. | 0.681 |
PAN3 | PEX2_057600 | A0A0A2K3K9 | A0A0A2IAP8 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] | Nuclear envelope, Cut8; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. | 0.860 |
PEX2_024750 | PAN3 | A0A0A2JGT4 | A0A0A2K3K9 | Uncharacterized protein family UPF0662. | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] | 0.681 |
PEX2_024750 | PEX2_057600 | A0A0A2JGT4 | A0A0A2IAP8 | Uncharacterized protein family UPF0662. | Nuclear envelope, Cut8; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. | 0.741 |
PEX2_050580 | PEX2_052640 | A0A0A2IZL3 | A0A0A2KDV1 | WD_REPEATS_REGION domain-containing protein. | Ribosomal protein L30, N-terminal. | 0.955 |
PEX2_050580 | PEX2_057600 | A0A0A2IZL3 | A0A0A2IAP8 | WD_REPEATS_REGION domain-containing protein. | Nuclear envelope, Cut8; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. | 0.843 |
PEX2_050580 | PEX2_057610 | A0A0A2IZL3 | A0A0A2JEN7 | WD_REPEATS_REGION domain-containing protein. | Helicase, C-terminal. | 0.837 |
PEX2_050580 | PEX2_063430 | A0A0A2IZL3 | A0A0A2JEH5 | WD_REPEATS_REGION domain-containing protein. | Armadillo-like helical. | 0.999 |
PEX2_050580 | PEX2_078060 | A0A0A2IZL3 | A0A0A2JLF4 | WD_REPEATS_REGION domain-containing protein. | Pre-mRNA cleavage complex II Clp1. | 0.987 |
PEX2_050580 | PEX2_089870 | A0A0A2IZL3 | A0A0A2L1I3 | WD_REPEATS_REGION domain-containing protein. | Ribosome biogenesis protein SSF1/SSF2. | 0.591 |
PEX2_052640 | PEX2_050580 | A0A0A2KDV1 | A0A0A2IZL3 | Ribosomal protein L30, N-terminal. | WD_REPEATS_REGION domain-containing protein. | 0.955 |
PEX2_052640 | PEX2_057600 | A0A0A2KDV1 | A0A0A2IAP8 | Ribosomal protein L30, N-terminal. | Nuclear envelope, Cut8; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. | 0.830 |
PEX2_052640 | PEX2_057610 | A0A0A2KDV1 | A0A0A2JEN7 | Ribosomal protein L30, N-terminal. | Helicase, C-terminal. | 0.899 |
PEX2_052640 | PEX2_063430 | A0A0A2KDV1 | A0A0A2JEH5 | Ribosomal protein L30, N-terminal. | Armadillo-like helical. | 0.900 |
PEX2_052640 | PEX2_078060 | A0A0A2KDV1 | A0A0A2JLF4 | Ribosomal protein L30, N-terminal. | Pre-mRNA cleavage complex II Clp1. | 0.756 |
PEX2_052640 | PEX2_089870 | A0A0A2KDV1 | A0A0A2L1I3 | Ribosomal protein L30, N-terminal. | Ribosome biogenesis protein SSF1/SSF2. | 0.866 |
PEX2_057600 | PAN3 | A0A0A2IAP8 | A0A0A2K3K9 | Nuclear envelope, Cut8; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] | 0.860 |
PEX2_057600 | PEX2_024750 | A0A0A2IAP8 | A0A0A2JGT4 | Nuclear envelope, Cut8; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. | Uncharacterized protein family UPF0662. | 0.741 |
PEX2_057600 | PEX2_050580 | A0A0A2IAP8 | A0A0A2IZL3 | Nuclear envelope, Cut8; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. | WD_REPEATS_REGION domain-containing protein. | 0.843 |
PEX2_057600 | PEX2_052640 | A0A0A2IAP8 | A0A0A2KDV1 | Nuclear envelope, Cut8; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. | Ribosomal protein L30, N-terminal. | 0.830 |