PEX2_026520 protein (Penicillium expansum) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PEX2_026520

Uncharacterized protein. (189 aa)

Predicted Functional Partners:

PEX2_064320

0.991

PEX2_106550

0.980

PEX2_075800

0.979

PEX2_002660

0.976

PEX2_035810

0.928

PEX2_012440

0.906

PEX2_072680

0.894

PEX2_036690

0.890

PEX2_038120

0.873

PEX2_055040

0.871

Your Current Organism:

Penicillium expansum

NCBI taxonomy Id: 27334
Other names: ATCC 7861, CBS 325.48, P. expansum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PEX2_002660	PEX2_012440	A0A0A2JPC8	A0A0A2I967	Pre-mRNA-splicing factor 38.	Zinc finger, U1-type.	0.983
PEX2_002660	PEX2_026520	A0A0A2JPC8	A0A0A2IJE8	Pre-mRNA-splicing factor 38.	Uncharacterized protein.	0.976
PEX2_002660	PEX2_035810	A0A0A2JPC8	A0A0A2KD69	Pre-mRNA-splicing factor 38.	Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family.	0.881
PEX2_002660	PEX2_036690	A0A0A2JPC8	A0A0A2IFV9	Pre-mRNA-splicing factor 38.	WD_REPEATS_REGION domain-containing protein.	0.893
PEX2_002660	PEX2_038120	A0A0A2JPC8	A0A0A2JG18	Pre-mRNA-splicing factor 38.	Small nuclear ribonucleoprotein G.	0.724
PEX2_002660	PEX2_055040	A0A0A2JPC8	A0A0A2L0V7	Pre-mRNA-splicing factor 38.	WD_REPEATS_REGION domain-containing protein.	0.916
PEX2_002660	PEX2_064320	A0A0A2JPC8	A0A0A2JJM9	Pre-mRNA-splicing factor 38.	SART-1 protein.	0.797
PEX2_002660	PEX2_072680	A0A0A2JPC8	A0A0A2JXE9	Pre-mRNA-splicing factor 38.	Nucleotide-binding, alpha-beta plait.	0.614
PEX2_002660	PEX2_075800	A0A0A2JPC8	A0A0A2JMK3	Pre-mRNA-splicing factor 38.	Micro-fibrillar-associated protein 1, C-terminal.	0.996
PEX2_002660	PEX2_106550	A0A0A2JPC8	A0A0A2JMB7	Pre-mRNA-splicing factor 38.	JAB_MPN domain-containing protein.	0.937
PEX2_012440	PEX2_002660	A0A0A2I967	A0A0A2JPC8	Zinc finger, U1-type.	Pre-mRNA-splicing factor 38.	0.983
PEX2_012440	PEX2_026520	A0A0A2I967	A0A0A2IJE8	Zinc finger, U1-type.	Uncharacterized protein.	0.906
PEX2_012440	PEX2_035810	A0A0A2I967	A0A0A2KD69	Zinc finger, U1-type.	Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family.	0.979
PEX2_012440	PEX2_036690	A0A0A2I967	A0A0A2IFV9	Zinc finger, U1-type.	WD_REPEATS_REGION domain-containing protein.	0.878
PEX2_012440	PEX2_038120	A0A0A2I967	A0A0A2JG18	Zinc finger, U1-type.	Small nuclear ribonucleoprotein G.	0.905
PEX2_012440	PEX2_055040	A0A0A2I967	A0A0A2L0V7	Zinc finger, U1-type.	WD_REPEATS_REGION domain-containing protein.	0.926
PEX2_012440	PEX2_064320	A0A0A2I967	A0A0A2JJM9	Zinc finger, U1-type.	SART-1 protein.	0.992
PEX2_012440	PEX2_072680	A0A0A2I967	A0A0A2JXE9	Zinc finger, U1-type.	Nucleotide-binding, alpha-beta plait.	0.933
PEX2_012440	PEX2_075800	A0A0A2I967	A0A0A2JMK3	Zinc finger, U1-type.	Micro-fibrillar-associated protein 1, C-terminal.	0.997
PEX2_012440	PEX2_106550	A0A0A2I967	A0A0A2JMB7	Zinc finger, U1-type.	JAB_MPN domain-containing protein.	0.908

page 1 of 6

Network Stats

number of nodes:

10

number of edges:

20

average node degree:

4

avg. local clustering coefficient:

0.931

expected number of edges:

9

PPI enrichment p-value:

0.00118

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006511

Ubiquitin-dependent protein catabolic process

11 of 822

1.83

5.12

3.68e-17

GO:0042176

Regulation of protein catabolic process

5 of 200

2.1

3.33

8.72e-08

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

6 of 447

1.83

3.04

4.26e-08

GO:0045862

Positive regulation of proteolysis

4 of 110

2.27

2.96

1.37e-06

GO:0010950

Positive regulation of endopeptidase activity

2 of 2

3.71

2.42

4.46e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061133

Endopeptidase activator activity

2 of 4

3.4

1.85

0.00046

GO:0030234

Enzyme regulator activity

6 of 1005

1.48

1.67

3.85e-05

GO:0043130

Ubiquitin binding

3 of 140

2.04

1.47

0.0014

GO:0070628

Proteasome binding

2 of 28

2.56

1.23

0.0057

GO:0036402

Proteasome-activating activity

2 of 33

2.49

1.18

0.0068

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005838

Proteasome regulatory particle

11 of 73

2.88

14.13

4.06e-29

GO:0008540

Proteasome regulatory particle, base subcomplex

6 of 44

2.84

7.16

2.24e-14

GO:0008541

Proteasome regulatory particle, lid subcomplex

5 of 26

2.99

6.31

1.74e-12

GO:0034515

Proteasome storage granule

4 of 7

3.46

5.85

2.43e-11

GO:0005634

Nucleus

11 of 12516

0.65

0.6

5.42e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12057

Proteasome complex

11 of 98

2.76

12.65

8.81e-27

CL:12059

Proteasome

10 of 85

2.78

11.84

9.95e-25

CL:12060

Proteasome complex

8 of 72

2.75

9.03

1.38e-18

CL:12181

Proteasome regulatory particle, lid subcomplex, and 26S proteasome non-ATPase regulatory subunit 4

4 of 10

3.31

5.11

5.15e-10

CL:12065

Proteasome regulatory particle, lid subcomplex, and 26S proteasome regulatory subunit P45-like

4 of 15

3.13

4.77

1.87e-09

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gmx03050

Proteasome

8 of 95

2.63

8.68

2.21e-18

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5689603

UCH proteinases

11 of 258

2.34

9.41

2.30e-23

MAP-9755511

KEAP1-NFE2L2 pathway

9 of 161

2.45

8.57

2.17e-19

MAP-453276

Regulation of mitotic cell cycle

9 of 176

2.41

8.34

3.78e-19

MAP-174143

APC/C-mediated degradation of cell cycle proteins

9 of 176

2.41

8.34

3.78e-19

MAP-187577

SCF(Skp2)-mediated degradation of p27/p21

8 of 112

2.56

8.33

5.72e-18

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000502

Proteasome complex

11 of 140

2.6

11.65

6.26e-26

GOCC:0008541

Proteasome regulatory particle, lid subcomplex

5 of 21

3.08

6.31

2.16e-12

GOCC:0034515

Proteasome storage granule

3 of 8

3.28

3.74

1.68e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0647

Proteasome

2 of 37

2.44

1.11

0.0091

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16550

UCH-binding domain

2 of 2

3.71

1.78

0.00064

PF04683

Proteasome complex subunit Rpn13 ubiquitin receptor

2 of 2

3.71

1.78

0.00064

PF01851

Proteasome/cyclosome repeat

2 of 4

3.4

1.78

0.00064

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044868

Rpn13/ADRM1, Pru domain

2 of 2

3.71

1.57

0.0015

IPR040623

26S proteasome regulatory subunit RPN2, C-terminal

2 of 2

3.71

1.57

0.0015

IPR038633

Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily

2 of 2

3.71

1.57

0.0015

IPR038108

RPN13, DEUBAD domain superfamily

2 of 7

3.16

1.57

0.0015

IPR035298

26S Proteasome non-ATPase regulatory subunit 13

2 of 2

3.71

1.57

0.0015

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

3 of 40

2.58

2.34

4.43e-05

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