node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | PEX2_019710 | A0A0A2JRP2 | A0A0A2JQ15 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Endonuclease/exonuclease/phosphatase. | 0.994 |
FEN1 | PEX2_047120 | A0A0A2JRP2 | A0A0A2I9E2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase family X. | 0.833 |
FEN1 | PEX2_048180 | A0A0A2JRP2 | A0A0A2JRU3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | XPG/RAD2 endonuclease. | 0.890 |
FEN1 | PEX2_060790 | A0A0A2JRP2 | A0A0A2IUC3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | BRCT domain-containing protein. | 0.776 |
FEN1 | PEX2_066730 | A0A0A2JRP2 | A0A0A2JU70 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Poly [ADP-ribose] polymerase. | 0.873 |
FEN1 | PEX2_072120 | A0A0A2JRP2 | A0A0A2JH90 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | VIT domain-containing protein. | 0.776 |
FEN1 | PEX2_096360 | A0A0A2JRP2 | A0A0A2IKR4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Zn(2)-C6 fungal-type domain-containing protein. | 0.719 |
FEN1 | PEX2_100590 | A0A0A2JRP2 | A0A0A2KKF0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase family X. | 0.866 |
FEN1 | PEX2_109860 | A0A0A2JRP2 | A0A0A2ILG0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.992 |
FEN1 | PEX2_109870 | A0A0A2JRP2 | A0A0A2IPI5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen, PCNA. | 0.992 |
PEX2_019710 | FEN1 | A0A0A2JQ15 | A0A0A2JRP2 | Endonuclease/exonuclease/phosphatase. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.994 |
PEX2_019710 | PEX2_047120 | A0A0A2JQ15 | A0A0A2I9E2 | Endonuclease/exonuclease/phosphatase. | DNA polymerase family X. | 0.790 |
PEX2_019710 | PEX2_048180 | A0A0A2JQ15 | A0A0A2JRU3 | Endonuclease/exonuclease/phosphatase. | XPG/RAD2 endonuclease. | 0.841 |
PEX2_019710 | PEX2_060790 | A0A0A2JQ15 | A0A0A2IUC3 | Endonuclease/exonuclease/phosphatase. | BRCT domain-containing protein. | 0.694 |
PEX2_019710 | PEX2_066730 | A0A0A2JQ15 | A0A0A2JU70 | Endonuclease/exonuclease/phosphatase. | Poly [ADP-ribose] polymerase. | 0.731 |
PEX2_019710 | PEX2_072120 | A0A0A2JQ15 | A0A0A2JH90 | Endonuclease/exonuclease/phosphatase. | VIT domain-containing protein. | 0.694 |
PEX2_019710 | PEX2_096360 | A0A0A2JQ15 | A0A0A2IKR4 | Endonuclease/exonuclease/phosphatase. | Zn(2)-C6 fungal-type domain-containing protein. | 0.679 |
PEX2_019710 | PEX2_100590 | A0A0A2JQ15 | A0A0A2KKF0 | Endonuclease/exonuclease/phosphatase. | DNA polymerase family X. | 0.841 |
PEX2_019710 | PEX2_109860 | A0A0A2JQ15 | A0A0A2ILG0 | Endonuclease/exonuclease/phosphatase. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.911 |
PEX2_019710 | PEX2_109870 | A0A0A2JQ15 | A0A0A2IPI5 | Endonuclease/exonuclease/phosphatase. | Proliferating cell nuclear antigen, PCNA. | 0.911 |