node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | PEX2_002550 | A0A0A2JRP2 | A0A0A2ISN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA-repair protein, UmuC-like, N-terminal. | 0.775 |
FEN1 | PEX2_015670 | A0A0A2JRP2 | A0A0A2K1V3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 3'-5' exonuclease domain-containing protein. | 0.999 |
FEN1 | PEX2_019530 | A0A0A2JRP2 | A0A0A2I2G2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.775 |
FEN1 | PEX2_020270 | A0A0A2JRP2 | A0A0A2JSF5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Sec20. | 0.951 |
FEN1 | PEX2_021530 | A0A0A2JRP2 | A0A0A2J0Y2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal. | 0.956 |
FEN1 | PEX2_041630 | A0A0A2JRP2 | A0A0A2L0B7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase. | 0.992 |
FEN1 | PEX2_047250 | A0A0A2JRP2 | A0A0A2IHI7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.977 |
FEN1 | PEX2_062550 | A0A0A2JRP2 | A0A0A2KSF0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.910 |
FEN1 | PEX2_073920 | A0A0A2JRP2 | A0A0A2KU99 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal. | 0.938 |
FEN1 | PEX2_109860 | A0A0A2JRP2 | A0A0A2ILG0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.992 |
PEX2_002550 | FEN1 | A0A0A2ISN1 | A0A0A2JRP2 | DNA-repair protein, UmuC-like, N-terminal. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.775 |
PEX2_002550 | PEX2_015670 | A0A0A2ISN1 | A0A0A2K1V3 | DNA-repair protein, UmuC-like, N-terminal. | 3'-5' exonuclease domain-containing protein. | 0.991 |
PEX2_002550 | PEX2_019530 | A0A0A2ISN1 | A0A0A2I2G2 | DNA-repair protein, UmuC-like, N-terminal. | Uncharacterized protein. | 0.765 |
PEX2_002550 | PEX2_020270 | A0A0A2ISN1 | A0A0A2JSF5 | DNA-repair protein, UmuC-like, N-terminal. | Sec20. | 0.994 |
PEX2_002550 | PEX2_021530 | A0A0A2ISN1 | A0A0A2J0Y2 | DNA-repair protein, UmuC-like, N-terminal. | DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal. | 0.992 |
PEX2_002550 | PEX2_041630 | A0A0A2ISN1 | A0A0A2L0B7 | DNA-repair protein, UmuC-like, N-terminal. | DNA polymerase. | 0.930 |
PEX2_002550 | PEX2_047250 | A0A0A2ISN1 | A0A0A2IHI7 | DNA-repair protein, UmuC-like, N-terminal. | DNA ligase. | 0.662 |
PEX2_002550 | PEX2_062550 | A0A0A2ISN1 | A0A0A2KSF0 | DNA-repair protein, UmuC-like, N-terminal. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.597 |
PEX2_002550 | PEX2_073920 | A0A0A2ISN1 | A0A0A2KU99 | DNA-repair protein, UmuC-like, N-terminal. | DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal. | 0.990 |
PEX2_002550 | PEX2_109860 | A0A0A2ISN1 | A0A0A2ILG0 | DNA-repair protein, UmuC-like, N-terminal. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.998 |