STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PEX2_025600Tyrosyl-DNA phosphodiesterase. (657 aa)    
Predicted Functional Partners:
PEX2_047450
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
    
 
 0.872
PEX2_035860
ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase.
    
 0.756
PEX2_073500
DNA helicase, ATP-dependent, Ku type.
     
 0.749
PEX2_091620
DNA repair protein.
   
 
 0.738
PEX2_096280
DNA-directed DNA polymerase, family X, beta-like, N-terminal.
   
 
 0.723
PEX2_060070
WLM domain-containing protein.
    
 
 0.700
PEX2_019710
Endonuclease/exonuclease/phosphatase.
   
 
 0.646
PEX2_027490
Ubiquitin supergroup.
    
 
 0.618
PEX2_084780
Aprataxin-like protein.
    
 
 0.610
PEX2_095020
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
     
 0.602
Your Current Organism:
Penicillium expansum
NCBI taxonomy Id: 27334
Other names: ATCC 7861, CBS 325.48, P. expansum
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