PEX2_012550 protein (Penicillium expansum) - STRING interaction network

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:

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Score

PEX2_012550

Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family. (493 aa)

Predicted Functional Partners:

PEX2_061850

0.688

PEX2_002620

0.688

PEX2_015670

0.684

PEX2_099310

0.618

PEX2_093650

0.573

PEX2_083770

0.573

PEX2_054170

0.573

PEX2_012560

0.573

PEX2_063870

0.570

PEX2_109900

0.570

Your Current Organism:

Penicillium expansum

NCBI taxonomy Id: 27334
Other names: ATCC 7861, CBS 325.48, P. expansum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PEX2_002620	PEX2_012550	A0A0A2JRM7	A0A0A2KWW4	Eukaryotic molybdopterin oxidoreductase.	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	0.688
PEX2_002620	PEX2_054170	A0A0A2JRM7	A0A0A2JWN3	Eukaryotic molybdopterin oxidoreductase.	Tryptophan synthase, beta chain.	0.663
PEX2_002620	PEX2_061850	A0A0A2JRM7	A0A0A2JDU4	Eukaryotic molybdopterin oxidoreductase.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.978
PEX2_002620	PEX2_083770	A0A0A2JRM7	A0A0A2JDV4	Eukaryotic molybdopterin oxidoreductase.	Tryptophan synthase.	0.663
PEX2_002620	PEX2_093650	A0A0A2JRM7	A0A0A2IV83	Eukaryotic molybdopterin oxidoreductase.	Tryptophan synthase.	0.663
PEX2_002620	PEX2_099310	A0A0A2JRM7	A0A0A2I2N8	Eukaryotic molybdopterin oxidoreductase.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.524
PEX2_002620	PEX2_109900	A0A0A2JRM7	A0A0A2JCI1	Eukaryotic molybdopterin oxidoreductase.	AB hydrolase-1 domain-containing protein.	0.460
PEX2_012550	PEX2_002620	A0A0A2KWW4	A0A0A2JRM7	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	Eukaryotic molybdopterin oxidoreductase.	0.688
PEX2_012550	PEX2_012560	A0A0A2KWW4	A0A0A2L437	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	Aromatic prenyltransferase, DMATS type.	0.573
PEX2_012550	PEX2_015670	A0A0A2KWW4	A0A0A2K1V3	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	3'-5' exonuclease domain-containing protein.	0.684
PEX2_012550	PEX2_054170	A0A0A2KWW4	A0A0A2JWN3	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	Tryptophan synthase, beta chain.	0.573
PEX2_012550	PEX2_061850	A0A0A2KWW4	A0A0A2JDU4	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.688
PEX2_012550	PEX2_063870	A0A0A2KWW4	A0A0A2IL23	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid; Belongs to the terpene cyclase/mutase family.	0.570
PEX2_012550	PEX2_083770	A0A0A2KWW4	A0A0A2JDV4	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	Tryptophan synthase.	0.573
PEX2_012550	PEX2_093650	A0A0A2KWW4	A0A0A2IV83	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	Tryptophan synthase.	0.573
PEX2_012550	PEX2_099310	A0A0A2KWW4	A0A0A2I2N8	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.618
PEX2_012550	PEX2_109900	A0A0A2KWW4	A0A0A2JCI1	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	AB hydrolase-1 domain-containing protein.	0.570
PEX2_012560	PEX2_012550	A0A0A2L437	A0A0A2KWW4	Aromatic prenyltransferase, DMATS type.	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	0.573
PEX2_015670	PEX2_012550	A0A0A2K1V3	A0A0A2KWW4	3'-5' exonuclease domain-containing protein.	Cytochrome P450, E-class, group I; Belongs to the cytochrome P450 family.	0.684
PEX2_015670	PEX2_099310	A0A0A2K1V3	A0A0A2I2N8	3'-5' exonuclease domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.982

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Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.053

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

5 of 86

2.39

3.56

1.04e-07

GO:0006572

Tyrosine catabolic process

3 of 10

3.1

2.83

7.36e-06

GO:0006121

Mitochondrial electron transport, succinate to ubiquinone

3 of 10

3.1

2.83

7.36e-06

GO:0006559

L-phenylalanine catabolic process

3 of 15

2.93

2.7

1.18e-05

GO:0019752

Carboxylic acid metabolic process

5 of 1336

1.2

0.91

0.0033

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008177

Succinate dehydrogenase (ubiquinone) activity

3 of 7

3.26

3.0

3.66e-06

GO:0004411

Homogentisate 1,2-dioxygenase activity

2 of 2

3.63

2.01

0.00024

GO:0016823

Hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

2 of 4

3.32

1.89

0.00039

GO:0009055

Electron transfer activity

3 of 117

2.03

1.55

0.00094

GO:0050660

Flavin adenine dinucleotide binding

3 of 184

1.84

1.26

0.0029

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

3 of 11

3.06

2.93

4.74e-06

GO:0070062

Extracellular exosome

3 of 139

1.96

1.59

0.00066

GO:0005739

Mitochondrion

8 of 2471

1.14

1.31

4.74e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:54561

Tricarboxylic acid cycle

4 of 50

2.53

2.82

4.90e-06

CL:54569

Succinate dehydrogenase (ubiquinone) activity, and CoA binding domain

2 of 5

3.23

1.55

0.0016

CL:55624

Tyrosine catabolism, and 3-dehydroquinate synthase

2 of 6

3.15

1.51

0.0019

CL:54387

Mixed, incl. Fumarylacetoacetase-like, C-terminal, and Maleylacetoacetate isomerase activity

2 of 6

3.15

1.51

0.0019

CL:54627

Fumarate reductase complex, and succinate-CoA ligase activity

2 of 17

2.7

1.22

0.0061

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00350

Tyrosine metabolism

4 of 98

2.24

3.07

7.11e-07

map00020

Citrate cycle (TCA cycle)

4 of 121

2.14

2.92

1.08e-06

map01200

Carbon metabolism

5 of 434

1.69

2.32

1.62e-06

map00620

Pyruvate metabolism

3 of 148

1.93

1.79

0.00022

map00190

Oxidative phosphorylation

3 of 369

1.54

1.15

0.0027

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71403

Citric acid cycle (TCA cycle)

5 of 65

2.51

4.27

5.18e-09

MAP-71406

Pyruvate metabolism and Citric Acid (TCA) cycle

5 of 131

2.21

3.47

7.64e-08

MAP-8963684

Tyrosine catabolism

3 of 10

3.1

3.19

1.58e-06

MAP-8963691

Phenylalanine and tyrosine metabolism

3 of 28

2.66

2.6

1.49e-05

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

5 of 364

1.76

2.26

5.74e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000862

Heart ventricle

3 of 422

1.48

1.25

0.0011

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

3 of 9

3.15

2.99

3.74e-06

GOCC:0005739

Mitochondrion

5 of 1491

1.15

0.92

0.0021

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0816

Tricarboxylic acid cycle

2 of 16

2.72

1.41

0.0027

KW-0809

Transit peptide

2 of 29

2.46

1.3

0.0041

KW-0249

Electron transport

2 of 43

2.29

1.26

0.0046

KW-0560

Oxidoreductase

3 of 291

1.64

1.11

0.0046

KW-0274

FAD

2 of 76

2.05

1.04

0.0106

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00890

FAD binding domain

3 of 14

2.96

2.54

2.31e-05

PF02910

Fumarate reductase flavoprotein C-term

2 of 2

3.63

1.82

0.00053

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030664

FAD-dependent oxidoreductase SdhA/FrdA/AprA

3 of 4

3.5

3.03

3.45e-06

IPR003953

FAD-dependent oxidoreductase 2, FAD binding domain

3 of 4

3.5

3.03

3.45e-06

IPR046452

Homogentisate 1,2-dioxygenase, N-terminal domain

2 of 2

3.63

1.67

0.0010

IPR037099

Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily

2 of 2

3.63

1.67

0.0010

IPR027477

Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily

2 of 2

3.63

1.67

0.0010

(more ...)

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