A0A0H2RLM0 protein (Schizopora paradoxa) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

A0A0H2RLM0

Uncharacterized protein. (296 aa)

Predicted Functional Partners:

A0A0H2RKT0

0.840

A0A0H2RTL4

0.840

A0A0H2S5B8

0.839

A0A0H2SBP6

0.839

A0A0H2R541

0.772

A0A0H2RHH8

0.772

A0A0H2RJQ2

0.772

A0A0H2RN77

0.772

A0A0H2RSY0

0.772

A0A0H2RJ95

0.760

Your Current Organism:

Schizopora paradoxa

NCBI taxonomy Id: 27342
Other names: Hyphodontia paradoxa, S. paradoxa

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0H2R541	A0A0H2RKT0	Nucleic acid-binding protein.	ERCC4 domain-containing protein.	0.908
A0A0H2R541	A0A0H2RLM0	Nucleic acid-binding protein.	Uncharacterized protein.	0.772
A0A0H2R541	A0A0H2S5B8	Nucleic acid-binding protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.981
A0A0H2R541	A0A0H2SBP6	Nucleic acid-binding protein.	Uncharacterized protein.	0.969
A0A0H2RHH8	A0A0H2RKT0	Lipase_GDSL domain-containing protein.	ERCC4 domain-containing protein.	0.896
A0A0H2RHH8	A0A0H2RLM0	Lipase_GDSL domain-containing protein.	Uncharacterized protein.	0.772
A0A0H2RHH8	A0A0H2S5B8	Lipase_GDSL domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.914
A0A0H2RHH8	A0A0H2SBP6	Lipase_GDSL domain-containing protein.	Uncharacterized protein.	0.914
A0A0H2RJ95	A0A0H2RLM0	Uncharacterized protein.	Uncharacterized protein.	0.760
A0A0H2RJQ2	A0A0H2RKT0	Nucleic acid-binding protein.	ERCC4 domain-containing protein.	0.908
A0A0H2RJQ2	A0A0H2RLM0	Nucleic acid-binding protein.	Uncharacterized protein.	0.772
A0A0H2RJQ2	A0A0H2S5B8	Nucleic acid-binding protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.981
A0A0H2RJQ2	A0A0H2SBP6	Nucleic acid-binding protein.	Uncharacterized protein.	0.969
A0A0H2RKT0	A0A0H2R541	ERCC4 domain-containing protein.	Nucleic acid-binding protein.	0.908
A0A0H2RKT0	A0A0H2RHH8	ERCC4 domain-containing protein.	Lipase_GDSL domain-containing protein.	0.896
A0A0H2RKT0	A0A0H2RJQ2	ERCC4 domain-containing protein.	Nucleic acid-binding protein.	0.908
A0A0H2RKT0	A0A0H2RLM0	ERCC4 domain-containing protein.	Uncharacterized protein.	0.840
A0A0H2RKT0	A0A0H2RN77	ERCC4 domain-containing protein.	Uncharacterized protein.	0.896
A0A0H2RKT0	A0A0H2RSY0	ERCC4 domain-containing protein.	Lipase_GDSL domain-containing protein.	0.896
A0A0H2RKT0	A0A0H2S5B8	ERCC4 domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.968

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

32

PPI enrichment p-value:

6.32e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000103

Sulfate assimilation

4 of 8

2.53

2.87

3.84e-06

GO:0006790

Sulfur compound metabolic process

5 of 139

1.39

1.14

0.0016

GO:0019379

Sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)

2 of 3

2.66

0.93

0.0203

GO:0070814

Hydrogen sulfide biosynthetic process

2 of 5

2.44

0.91

0.0213

GO:0042128

Nitrate assimilation

2 of 6

2.36

0.88

0.0243

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0020037

Heme binding

6 of 53

1.89

2.99

1.13e-07

GO:0043546

Molybdopterin cofactor binding

3 of 4

2.71

2.47

2.83e-05

GO:0030151

Molybdenum ion binding

3 of 5

2.61

2.39

3.62e-05

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

2.83

1.42

0.0027

GO:0004783

Sulfite reductase (NADPH) activity

2 of 2

2.83

1.42

0.0027

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009337

Sulfite reductase complex (NADPH)

2 of 2

2.83

1.13

0.0089

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9918

Mixed, incl. Nitrate metabolic process, and Sulfate assimilation

10 of 26

2.42

8.8

2.34e-20

CL:9920

Nitrate metabolic process, and O2/CO2 exchange in erythrocytes

5 of 10

2.53

4.57

1.30e-09

CL:9947

Sulfate assimilation

4 of 5

2.74

3.9

5.12e-08

CL:9923

Nitrate reductase activity, and Nitrate import

3 of 5

2.61

2.56

1.71e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00920

Sulfur metabolism

6 of 31

2.12

4.18

6.17e-10

map01100

Metabolic pathways

9 of 1782

0.54

0.4

0.0061

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1480926

O2/CO2 exchange in erythrocytes

2 of 6

2.36

0.71

0.0497

MAP-1237044

Erythrocytes take up carbon dioxide and release oxygen

2 of 6

2.36

0.71

0.0497

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0500

Molybdenum

3 of 6

2.53

2.49

2.21e-05

KW-0408

Iron

5 of 60

1.75

2.29

4.18e-06

KW-0349

Heme

3 of 24

1.93

1.63

0.00051

KW-0274

FAD

3 of 36

1.75

1.39

0.0012

KW-0560

Oxidoreductase

4 of 156

1.24

0.99

0.0022

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00175

Oxidoreductase NAD-binding domain

4 of 8

2.53

3.15

1.07e-06

PF03404

Mo-co oxidoreductase dimerisation domain

3 of 3

2.83

2.56

2.04e-05

PF00174

Oxidoreductase molybdopterin binding domain

3 of 3

2.83

2.56

2.04e-05

PF00970

Oxidoreductase FAD-binding domain

3 of 5

2.61

2.45

2.85e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001433

Oxidoreductase FAD/NAD(P)-binding

4 of 8

2.53

2.92

3.08e-06

IPR017938

Riboflavin synthase-like beta-barrel

4 of 13

2.32

2.65

7.38e-06

IPR017927

FAD-binding domain, ferredoxin reductase-type

4 of 15

2.26

2.61

8.00e-06

IPR039261

Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

4 of 17

2.21

2.55

9.25e-06

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

3 of 3

2.83

2.53

2.34e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 21

1.99

1.47

0.0013

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