VP01_637g6 protein (Puccinia sorghi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

VP01_637g6

Uncharacterized protein. (167 aa)

Predicted Functional Partners:

VP01_709g4

0.601

VP01_595g9

0.601

VP01_1624g4

0.601

VP01_1037g16

0.601

VP01_218g18

0.587

GHPOD

0.576

VP01_3035g2

0.560

VP01_265g20

0.560

VP01_759g3

0.536

VP01_2211g2

0.536

Your Current Organism:

Puccinia sorghi

NCBI taxonomy Id: 27349
Other names: P. sorghi

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GHPOD	VP01_637g6	A0A0L6VC09	A0A0L6UFY7	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Uncharacterized protein.	0.576
VP01_1037g16	VP01_1624g4	A0A0L6VVX3	A0A0L6VGZ1	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	0.884
VP01_1037g16	VP01_218g18	A0A0L6VVX3	A0A0L6VB09	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	L-lactate dehydrogenase (Cytochrome); Belongs to the cytochrome b5 family.	0.840
VP01_1037g16	VP01_265g20	A0A0L6VVX3	A0A0L6V430	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	PWWP domain-containing protein.	0.466
VP01_1037g16	VP01_3035g2	A0A0L6VVX3	A0A0L6V0T0	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Uncharacterized protein.	0.466
VP01_1037g16	VP01_595g9	A0A0L6VVX3	A0A0L6UHP5	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.844
VP01_1037g16	VP01_637g6	A0A0L6VVX3	A0A0L6UFY7	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Uncharacterized protein.	0.601
VP01_1037g16	VP01_709g4	A0A0L6VVX3	A0A0L6UDP2	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	VPS13_mid_rpt domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	0.848
VP01_1624g4	VP01_1037g16	A0A0L6VGZ1	A0A0L6VVX3	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.884
VP01_1624g4	VP01_218g18	A0A0L6VGZ1	A0A0L6VB09	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	L-lactate dehydrogenase (Cytochrome); Belongs to the cytochrome b5 family.	0.840
VP01_1624g4	VP01_265g20	A0A0L6VGZ1	A0A0L6V430	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	PWWP domain-containing protein.	0.466
VP01_1624g4	VP01_3035g2	A0A0L6VGZ1	A0A0L6V0T0	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	Uncharacterized protein.	0.466
VP01_1624g4	VP01_595g9	A0A0L6VGZ1	A0A0L6UHP5	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.960
VP01_1624g4	VP01_637g6	A0A0L6VGZ1	A0A0L6UFY7	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	Uncharacterized protein.	0.601
VP01_1624g4	VP01_709g4	A0A0L6VGZ1	A0A0L6UDP2	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	VPS13_mid_rpt domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	0.865
VP01_218g18	VP01_1037g16	A0A0L6VB09	A0A0L6VVX3	L-lactate dehydrogenase (Cytochrome); Belongs to the cytochrome b5 family.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.840
VP01_218g18	VP01_1624g4	A0A0L6VB09	A0A0L6VGZ1	L-lactate dehydrogenase (Cytochrome); Belongs to the cytochrome b5 family.	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	0.840
VP01_218g18	VP01_265g20	A0A0L6VB09	A0A0L6V430	L-lactate dehydrogenase (Cytochrome); Belongs to the cytochrome b5 family.	PWWP domain-containing protein.	0.644
VP01_218g18	VP01_3035g2	A0A0L6VB09	A0A0L6V0T0	L-lactate dehydrogenase (Cytochrome); Belongs to the cytochrome b5 family.	Uncharacterized protein.	0.644
VP01_218g18	VP01_595g9	A0A0L6VB09	A0A0L6UHP5	L-lactate dehydrogenase (Cytochrome); Belongs to the cytochrome b5 family.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.840

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.879

expected number of edges:

42

PPI enrichment p-value:

0.995

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

5 of 22

1.87

2.29

9.82e-06

GO:0009408

Response to heat

3 of 10

1.99

1.23

0.0041

GO:0051603

Proteolysis involved in protein catabolic process

2 of 4

2.21

0.79

0.0344

GO:0050821

Protein stabilization

2 of 4

2.21

0.79

0.0344

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005515

Protein binding

6 of 48

1.61

2.14

2.81e-06

GO:0051082

Unfolded protein binding

3 of 10

1.99

1.36

0.0022

GO:0140662

ATP-dependent protein folding chaperone

2 of 4

2.21

0.88

0.0237

GO:0004176

ATP-dependent peptidase activity

2 of 4

2.21

0.88

0.0237

GO:0140657

ATP-dependent activity

5 of 137

1.08

0.74

0.0085

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1235

0.46

0.38

0.0011

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36350115

(2022) Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria.

2 of 3

2.34

1.12

0.0086

PMID:32093084

(2020) Adaptation to Photooxidative Stress: Common and Special Strategies of the Alphaproteobacteria Rhodobacter sphaeroides and Rhodobacter capsulatus.

3 of 26

1.58

0.98

0.0086

PMID:33780465

(2021) Adaptation of Dinoroseobacter shibae to oxidative stress and the specific role of RirA.

3 of 51

1.28

0.75

0.0186

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:378

Chaperone, and Cellular response to heat

10 of 16

2.31

7.89

5.09e-19

CL:381

Stress response, and Protein folding chaperone

8 of 10

2.42

6.85

2.99e-15

CL:384

Protein folding chaperone, and Chaperone binding

4 of 5

2.42

3.15

8.49e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236975

Antigen processing-Cross presentation

3 of 4

2.39

2.58

1.19e-05

MAP-983169

Class I MHC mediated antigen processing & presentation

3 of 6

2.21

2.47

1.42e-05

MAP-1280218

Adaptive Immune System

3 of 6

2.21

2.47

1.42e-05

MAP-168256

Immune System

3 of 27

1.56

1.48

0.00033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009368

Endopeptidase Clp complex

2 of 3

2.34

0.86

0.0262

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

8 of 16

2.21

5.89

3.95e-14

KW-0143

Chaperone

5 of 23

1.85

2.62

9.96e-07

KW-0720

Serine protease

2 of 5

2.12

1.09

0.0088

KW-0645

Protease

3 of 34

1.46

0.93

0.0088

KW-0963

Cytoplasm

7 of 252

0.96

0.89

0.00018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00011

Hsp20/alpha crystallin family

3 of 3

2.51

1.95

0.00024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008978

HSP20-like chaperone

3 of 3

2.51

1.73

0.00064

IPR002068

Alpha crystallin/Hsp20 domain

3 of 3

2.51

1.73

0.00064

IPR037913

Small heat shock protein IbpA/IbpB, ACD domain

2 of 2

2.51

0.88

0.0255

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About