VP01_358g4 protein (Puccinia sorghi) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

VP01_358g4

Acyl-coenzyme A oxidase. (862 aa)

Predicted Functional Partners:

VP01_65g14

0.980

VP01_221g5

0.980

VP01_3396g2

0.977

VP01_1179g3

0.977

VP01_15g5

0.976

VP01_951g10

0.974

VP01_1732g2

0.967

acs

0.966

mmsA

0.953

VP01_123g5

0.951

Your Current Organism:

Puccinia sorghi

NCBI taxonomy Id: 27349
Other names: P. sorghi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
VP01_1179g3	VP01_123g5	A0A0L6VR52	A0A0L6VR50	MaoC-like domain-containing protein.	Acyl-CoA dehydrogenase.	0.872
VP01_1179g3	VP01_15g5	A0A0L6VR52	A0A0L6VHB4	MaoC-like domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.833
VP01_1179g3	VP01_1732g2	A0A0L6VR52	A0A0L6VFA9	MaoC-like domain-containing protein.	3-hydroxyacyl-CoA dehydrogenase.	0.810
VP01_1179g3	VP01_221g5	A0A0L6VR52	A0A0L6VAM5	MaoC-like domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.964
VP01_1179g3	VP01_3396g2	A0A0L6VR52	A0A0L6UWM2	MaoC-like domain-containing protein.	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.833
VP01_1179g3	VP01_358g4	A0A0L6VR52	A0A0L6UV99	MaoC-like domain-containing protein.	Acyl-coenzyme A oxidase.	0.977
VP01_1179g3	VP01_65g14	A0A0L6VR52	A0A0L6UF57	MaoC-like domain-containing protein.	Acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.964
VP01_1179g3	VP01_951g10	A0A0L6VR52	A0A0L6U8H1	MaoC-like domain-containing protein.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.962
VP01_1179g3	acs	A0A0L6VR52	A0A0L6V2L6	MaoC-like domain-containing protein.	Acetyl-coenzyme A synthetase.	0.847
VP01_1179g3	mmsA	A0A0L6VR52	A0A0L6VR83	MaoC-like domain-containing protein.	Methylmalonate-semialdehyde dehydrogenase (Acylating).	0.415
VP01_123g5	VP01_1179g3	A0A0L6VR50	A0A0L6VR52	Acyl-CoA dehydrogenase.	MaoC-like domain-containing protein.	0.872
VP01_123g5	VP01_15g5	A0A0L6VR50	A0A0L6VHB4	Acyl-CoA dehydrogenase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.987
VP01_123g5	VP01_1732g2	A0A0L6VR50	A0A0L6VFA9	Acyl-CoA dehydrogenase.	3-hydroxyacyl-CoA dehydrogenase.	0.921
VP01_123g5	VP01_221g5	A0A0L6VR50	A0A0L6VAM5	Acyl-CoA dehydrogenase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.972
VP01_123g5	VP01_3396g2	A0A0L6VR50	A0A0L6UWM2	Acyl-CoA dehydrogenase.	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.972
VP01_123g5	VP01_358g4	A0A0L6VR50	A0A0L6UV99	Acyl-CoA dehydrogenase.	Acyl-coenzyme A oxidase.	0.951
VP01_123g5	VP01_65g14	A0A0L6VR50	A0A0L6UF57	Acyl-CoA dehydrogenase.	Acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.972
VP01_123g5	VP01_951g10	A0A0L6VR50	A0A0L6U8H1	Acyl-CoA dehydrogenase.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.976
VP01_123g5	acs	A0A0L6VR50	A0A0L6V2L6	Acyl-CoA dehydrogenase.	Acetyl-coenzyme A synthetase.	0.822
VP01_123g5	mmsA	A0A0L6VR50	A0A0L6VR83	Acyl-CoA dehydrogenase.	Methylmalonate-semialdehyde dehydrogenase (Acylating).	0.644

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

2.61e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016052

Carbohydrate catabolic process

5 of 53

1.62

1.88

2.59e-05

GO:0006012

Galactose metabolic process

3 of 8

2.22

1.86

0.00027

GO:0005975

Carbohydrate metabolic process

11 of 334

1.16

1.69

2.40e-10

GO:1901575

Organic substance catabolic process

7 of 179

1.23

1.39

1.84e-05

GO:0046514

Ceramide catabolic process

2 of 5

2.24

1.05

0.0111

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004565

Beta-galactosidase activity

8 of 19

2.27

6.09

2.97e-14

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

10 of 135

1.51

3.03

9.35e-13

GO:0004348

Glucosylceramidase activity

2 of 5

2.24

1.12

0.0084

GO:0003824

Catalytic activity

11 of 2047

0.37

0.3

0.0083

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009341

Beta-galactosidase complex

8 of 19

2.27

6.34

6.04e-15

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5942

Galactose metabolism

8 of 17

2.31

6.24

2.53e-14

CL:5961

Glycoside hydrolase, family 2, and Glycoside hydrolase, family 35

6 of 6

2.64

5.71

8.44e-12

CL:6174

Ceramide metabolic process, and Protein of unknown function DUF2961

2 of 7

2.1

0.94

0.0176

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fgi00052

Galactose metabolism

9 of 26

2.18

6.62

1.08e-16

fgi00600

Sphingolipid metabolism

7 of 14

2.34

5.98

1.72e-13

fgi00511

Other glycan degradation

7 of 32

1.98

4.41

1.50e-11

fgi01100

Metabolic pathways

8 of 598

0.77

0.67

0.00019

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168249

Innate Immune System

5 of 57

1.58

2.08

3.48e-06

MAP-168256

Immune System

5 of 73

1.48

1.86

5.58e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009341

Beta-galactosidase complex

3 of 11

2.08

1.6

0.00078

GOCC:0030117

Membrane coat

2 of 8

2.04

0.85

0.0258

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

6 of 54

1.69

2.55

2.42e-07

KW-0378

Hydrolase

8 of 333

1.02

1.1

7.51e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00703

Glycosyl hydrolases family 2

4 of 7

2.4

2.89

2.76e-06

PF02836

Glycosyl hydrolases family 2, TIM barrel domain

4 of 8

2.34

2.86

2.76e-06

PF02837

Glycosyl hydrolases family 2, sugar binding domain

4 of 10

2.24

2.81

2.78e-06

PF16355

Domain of unknown function (DUF4982)

3 of 3

2.64

2.48

2.54e-05

PF02449

Beta-galactosidase

3 of 7

2.27

2.05

0.00012

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006101

Glycoside hydrolase, family 2

4 of 4

2.64

3.36

4.87e-07

IPR006104

Glycosyl hydrolases family 2, sugar binding domain

4 of 7

2.4

2.99

1.72e-06

IPR006102

Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich

4 of 7

2.4

2.99

1.72e-06

IPR036156

Beta-Galactosidase/glucuronidase domain superfamily

4 of 8

2.34

2.96

1.72e-06

IPR006103

Glycoside hydrolase family 2, catalytic domain

4 of 8

2.34

2.96

1.72e-06

(more ...)

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