VP01_1237g6 protein (Puccinia sorghi) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

VP01_1237g6

BRO1 domain-containing protein. (472 aa)

Predicted Functional Partners:

VP01_3559g3

0.940

VP01_926g4

0.781

VP01_145g3

0.747

VP01_1278g2

0.731

VP01_4g16

0.717

VP01_2244g1

0.717

VP01_1373g8

0.717

VP01_4222g1

0.660

VP01_2608g3

0.660

VP01_554g5

0.629

Your Current Organism:

Puccinia sorghi

NCBI taxonomy Id: 27349
Other names: P. sorghi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
VP01_1237g6	VP01_1278g2	A0A0L6VPP0	A0A0L6VP33	BRO1 domain-containing protein.	Uncharacterized protein.	0.731
VP01_1237g6	VP01_1373g8	A0A0L6VPP0	A0A0L6VNG7	BRO1 domain-containing protein.	AN1-type domain-containing protein.	0.717
VP01_1237g6	VP01_145g3	A0A0L6VPP0	A0A0L6VLQ3	BRO1 domain-containing protein.	Uncharacterized protein.	0.747
VP01_1237g6	VP01_2244g1	A0A0L6VPP0	A0A0L6VAE3	BRO1 domain-containing protein.	Uncharacterized protein.	0.717
VP01_1237g6	VP01_2608g3	A0A0L6VPP0	A0A0L6V4I5	BRO1 domain-containing protein.	SH3 domain-containing protein.	0.660
VP01_1237g6	VP01_3559g3	A0A0L6VPP0	A0A0L6UW80	BRO1 domain-containing protein.	Uncharacterized protein.	0.940
VP01_1237g6	VP01_4222g1	A0A0L6VPP0	A0A0L6USJ5	BRO1 domain-containing protein.	Uncharacterized protein.	0.660
VP01_1237g6	VP01_4g16	A0A0L6VPP0	A0A0L6ULP7	BRO1 domain-containing protein.	Uncharacterized protein.	0.717
VP01_1237g6	VP01_554g5	A0A0L6VPP0	A0A0L6UL94	BRO1 domain-containing protein.	Uncharacterized protein.	0.629
VP01_1237g6	VP01_926g4	A0A0L6VPP0	A0A0L6U994	BRO1 domain-containing protein.	Vacuolar sorting-associated protein 4; Belongs to the AAA ATPase family.	0.781
VP01_1278g2	VP01_1237g6	A0A0L6VP33	A0A0L6VPP0	Uncharacterized protein.	BRO1 domain-containing protein.	0.731
VP01_1278g2	VP01_1373g8	A0A0L6VP33	A0A0L6VNG7	Uncharacterized protein.	AN1-type domain-containing protein.	0.613
VP01_1278g2	VP01_145g3	A0A0L6VP33	A0A0L6VLQ3	Uncharacterized protein.	Uncharacterized protein.	0.595
VP01_1278g2	VP01_2244g1	A0A0L6VP33	A0A0L6VAE3	Uncharacterized protein.	Uncharacterized protein.	0.618
VP01_1278g2	VP01_3559g3	A0A0L6VP33	A0A0L6UW80	Uncharacterized protein.	Uncharacterized protein.	0.988
VP01_1278g2	VP01_4g16	A0A0L6VP33	A0A0L6ULP7	Uncharacterized protein.	Uncharacterized protein.	0.618
VP01_1278g2	VP01_926g4	A0A0L6VP33	A0A0L6U994	Uncharacterized protein.	Vacuolar sorting-associated protein 4; Belongs to the AAA ATPase family.	0.962
VP01_1373g8	VP01_1237g6	A0A0L6VNG7	A0A0L6VPP0	AN1-type domain-containing protein.	BRO1 domain-containing protein.	0.717
VP01_1373g8	VP01_1278g2	A0A0L6VNG7	A0A0L6VP33	AN1-type domain-containing protein.	Uncharacterized protein.	0.613
VP01_1373g8	VP01_145g3	A0A0L6VNG7	A0A0L6VLQ3	AN1-type domain-containing protein.	Uncharacterized protein.	0.924

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.781

expected number of edges:

11

PPI enrichment p-value:

0.00219

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009167

Purine ribonucleoside monophosphate metabolic process

5 of 11

1.93

2.86

4.00e-07

GO:0009150

Purine ribonucleotide metabolic process

8 of 49

1.49

2.33

2.79e-08

GO:0009165

Nucleotide biosynthetic process

8 of 60

1.4

2.12

2.79e-08

GO:0009132

Nucleoside diphosphate metabolic process

4 of 14

1.73

1.95

3.70e-05

GO:0046037

GMP metabolic process

3 of 5

2.05

1.92

0.00015

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019205

Nucleobase-containing compound kinase activity

3 of 11

1.71

0.97

0.0112

GO:0004748

Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

2 of 2

2.27

0.93

0.0189

GO:0004385

Guanylate kinase activity

2 of 2

2.27

0.93

0.0189

GO:0106130

Purine phosphoribosyltransferase activity

2 of 4

1.97

0.91

0.0189

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

3 of 15

1.57

0.89

0.0144

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005971

Ribonucleoside-diphosphate reductase complex

2 of 2

2.27

0.98

0.0153

GO:0005737

Cytoplasm

10 of 713

0.42

0.31

0.0153

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:673

Mixed, incl. Purine nucleoside monophosphate metabolic process, and Ribonucleoside hydrolase-like

7 of 21

1.8

3.37

1.38e-09

CL:676

Purine nucleoside monophosphate metabolic process, and Ribonucleoside hydrolase-like

6 of 14

1.9

3.33

1.26e-08

CL:671

Mixed, incl. Nucleoside monophosphate metabolic process, and Pteridine-containing compound metabolic process

9 of 40

1.62

3.24

2.71e-11

CL:678

Purine nucleoside monophosphate biosynthetic process

2 of 6

1.8

0.69

0.0475

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

11 of 72

1.46

2.97

2.17e-14

map00240

Pyrimidine metabolism

3 of 43

1.12

0.55

0.0489

map01100

Metabolic pathways

11 of 614

0.53

0.46

8.76e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168249

Innate Immune System

3 of 19

1.47

1.05

0.0042

MAP-168256

Immune System

3 of 24

1.37

1.0

0.0042

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005971

Ribonucleoside-diphosphate reductase complex

2 of 2

2.27

0.82

0.0314

GOCC:0005622

Intracellular

10 of 759

0.39

0.28

0.0362

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0328

Glycosyltransferase

3 of 11

1.71

1.08

0.0063

KW-0660

Purine salvage

2 of 3

2.1

0.9

0.0205

KW-0808

Transferase

6 of 223

0.7

0.43

0.0264

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029057

Phosphoribosyltransferase-like

3 of 10

1.75

0.81

0.0266

IPR000836

Phosphoribosyltransferase domain

3 of 10

1.75

0.81

0.0266

IPR008145

Guanylate kinase/L-type calcium channel beta subunit

2 of 2

2.27

0.74

0.0438

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00072

Guanylate kinase homologues.

2 of 2

2.27

1.04

0.0116

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