node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDG13812.1 | gcvP | SMDB11_3248 | SMDB11_3310 | Hypothetical protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.947 |
CDG13812.1 | glyA | SMDB11_3248 | SMDB11_3026 | Hypothetical protein. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.631 |
CDG13812.1 | purL | SMDB11_3248 | SMDB11_3042 | Hypothetical protein. | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.986 |
CDG14557.1 | fumA | SMDB11_3999 | SMDB11_3428 | Putative pyridine nucleotide-disulphide oxidoreductase. | Fumarate hydratase, aerobic, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.402 |
CDG14557.1 | gcvH | SMDB11_3999 | SMDB11_3311 | Putative pyridine nucleotide-disulphide oxidoreductase. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.957 |
CDG14557.1 | gcvP | SMDB11_3999 | SMDB11_3310 | Putative pyridine nucleotide-disulphide oxidoreductase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.948 |
CDG14557.1 | gcvT | SMDB11_3999 | SMDB11_3312 | Putative pyridine nucleotide-disulphide oxidoreductase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.937 |
CDG14557.1 | glyA | SMDB11_3999 | SMDB11_3026 | Putative pyridine nucleotide-disulphide oxidoreductase. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
CDG14557.1 | lpdA | SMDB11_3999 | SMDB11_3417 | Putative pyridine nucleotide-disulphide oxidoreductase. | Lipoamide dehydrogenase, E3 component is partof three enzyme complexes. | 0.911 |
fumA | CDG14557.1 | SMDB11_3428 | SMDB11_3999 | Fumarate hydratase, aerobic, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Putative pyridine nucleotide-disulphide oxidoreductase. | 0.402 |
fumA | gcvP | SMDB11_3428 | SMDB11_3310 | Fumarate hydratase, aerobic, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
fumA | glyA | SMDB11_3428 | SMDB11_3026 | Fumarate hydratase, aerobic, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.502 |
fumA | lpdA | SMDB11_3428 | SMDB11_3417 | Fumarate hydratase, aerobic, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Lipoamide dehydrogenase, E3 component is partof three enzyme complexes. | 0.402 |
gcvH | CDG14557.1 | SMDB11_3311 | SMDB11_3999 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Putative pyridine nucleotide-disulphide oxidoreductase. | 0.957 |
gcvH | gcvP | SMDB11_3311 | SMDB11_3310 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | SMDB11_3311 | SMDB11_3312 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | glyA | SMDB11_3311 | SMDB11_3026 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.970 |
gcvH | lpdA | SMDB11_3311 | SMDB11_3417 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoamide dehydrogenase, E3 component is partof three enzyme complexes. | 0.965 |
gcvH | purL | SMDB11_3311 | SMDB11_3042 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.478 |
gcvP | CDG13812.1 | SMDB11_3310 | SMDB11_3248 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Hypothetical protein. | 0.947 |