node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDG10938.1 | queF | SMDB11_0347 | SMDB11_3191 | Putative exported protein. | NADPH-dependent 7-cyano-7-deazaguaninereductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.775 |
CDG10938.1 | queF-2 | SMDB11_0347 | SMDB11_3466 | Putative exported protein. | Putative NADPH-dependent 7-cyano-7-deazaguaninereductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.775 |
CDG14029.1 | queF | SMDB11_3465 | SMDB11_3191 | Putative membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. | NADPH-dependent 7-cyano-7-deazaguaninereductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.630 |
CDG14029.1 | queF-2 | SMDB11_3465 | SMDB11_3466 | Putative membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. | Putative NADPH-dependent 7-cyano-7-deazaguaninereductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.912 |
folE | queA | SMDB11_0826 | SMDB11_0312 | GTP cyclohydrolase I. | S-adenosylmethionine: tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.779 |
folE | queC | SMDB11_0826 | SMDB11_0349 | GTP cyclohydrolase I. | Queuosine biosynthesis protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.866 |
folE | queE | SMDB11_0826 | SMDB11_0120 | GTP cyclohydrolase I. | Radical SAM superfamily protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.884 |
folE | queF | SMDB11_0826 | SMDB11_3191 | GTP cyclohydrolase I. | NADPH-dependent 7-cyano-7-deazaguaninereductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.856 |
folE | queF-2 | SMDB11_0826 | SMDB11_3466 | GTP cyclohydrolase I. | Putative NADPH-dependent 7-cyano-7-deazaguaninereductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.856 |
folE | queG | SMDB11_0826 | SMDB11_4476 | GTP cyclohydrolase I. | Putative 4Fe-4S binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. | 0.839 |
folE | sscR | SMDB11_0826 | SMDB11_0122 | GTP cyclohydrolase I. | 6-pyruvoyl tetrahydrobiopterin synthase. | 0.992 |
folE | tgt | SMDB11_0826 | SMDB11_0313 | GTP cyclohydrolase I. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.848 |
queA | folE | SMDB11_0312 | SMDB11_0826 | S-adenosylmethionine: tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | GTP cyclohydrolase I. | 0.779 |
queA | queC | SMDB11_0312 | SMDB11_0349 | S-adenosylmethionine: tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Queuosine biosynthesis protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.587 |
queA | queE | SMDB11_0312 | SMDB11_0120 | S-adenosylmethionine: tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Radical SAM superfamily protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.763 |
queA | queF | SMDB11_0312 | SMDB11_3191 | S-adenosylmethionine: tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | NADPH-dependent 7-cyano-7-deazaguaninereductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.843 |
queA | queF-2 | SMDB11_0312 | SMDB11_3466 | S-adenosylmethionine: tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Putative NADPH-dependent 7-cyano-7-deazaguaninereductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.843 |
queA | queG | SMDB11_0312 | SMDB11_4476 | S-adenosylmethionine: tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Putative 4Fe-4S binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. | 0.912 |
queA | sscR | SMDB11_0312 | SMDB11_0122 | S-adenosylmethionine: tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 6-pyruvoyl tetrahydrobiopterin synthase. | 0.772 |
queA | tgt | SMDB11_0312 | SMDB11_0313 | S-adenosylmethionine: tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.992 |