SDE04117.1 protein (Peptococcus niger) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

SDE04117.1

Arylsulfotransferase (ASST). (472 aa)

Predicted Functional Partners:

SDE04080.1

0.695

SDD66254.1

0.659

SDD72535.1

0.616

SDD52007.1

0.615

SDE09569.1

0.602

SDD84409.1

0.584

ribBA

0.570

SDD12288.1

0.484

SDD10378.1

0.468

SDD95684.1

0.468

Your Current Organism:

Peptococcus niger

NCBI taxonomy Id: 2741
Other names: ATCC 27731, DSM 20475, JCM 6506, Micrococcus niger, NCTC 11805, P. niger, VPI 7953

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDD10378.1	SDD72535.1	SAMN04489866_101185	SAMN04489866_10641	Thioredoxin reductase (NADPH).	Arylsulfotransferase (ASST).	0.564
SDD10378.1	SDD95684.1	SAMN04489866_101185	SAMN04489866_11131	Thioredoxin reductase (NADPH).	Thioredoxin reductase (NADPH).	0.719
SDD10378.1	SDE04117.1	SAMN04489866_101185	SAMN04489866_11421	Thioredoxin reductase (NADPH).	Arylsulfotransferase (ASST).	0.468
SDD10378.1	ribBA	SAMN04489866_101185	SAMN04489866_101160	Thioredoxin reductase (NADPH).	3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.656
SDD12288.1	SDD52007.1	SAMN04489866_101241	SAMN04489866_10416	Nitrate reductase gamma subunit.	Type I phosphodiesterase / nucleotide pyrophosphatase.	0.669
SDD12288.1	SDD66254.1	SAMN04489866_101241	SAMN04489866_10573	Nitrate reductase gamma subunit.	Di-and tricarboxylate transporter.	0.484
SDD12288.1	SDD72535.1	SAMN04489866_101241	SAMN04489866_10641	Nitrate reductase gamma subunit.	Arylsulfotransferase (ASST).	0.707
SDD12288.1	SDD84409.1	SAMN04489866_101241	SAMN04489866_10857	Nitrate reductase gamma subunit.	Type I phosphodiesterase / nucleotide pyrophosphatase.	0.706
SDD12288.1	SDE04080.1	SAMN04489866_101241	SAMN04489866_11420	Nitrate reductase gamma subunit.	Sodium:sulfate symporter transmembrane region.	0.411
SDD12288.1	SDE04117.1	SAMN04489866_101241	SAMN04489866_11421	Nitrate reductase gamma subunit.	Arylsulfotransferase (ASST).	0.484
SDD12288.1	SDE09569.1	SAMN04489866_101241	SAMN04489866_11821	Nitrate reductase gamma subunit.	Di-and tricarboxylate transporter.	0.442
SDD52007.1	SDD12288.1	SAMN04489866_10416	SAMN04489866_101241	Type I phosphodiesterase / nucleotide pyrophosphatase.	Nitrate reductase gamma subunit.	0.669
SDD52007.1	SDD66254.1	SAMN04489866_10416	SAMN04489866_10573	Type I phosphodiesterase / nucleotide pyrophosphatase.	Di-and tricarboxylate transporter.	0.510
SDD52007.1	SDD72535.1	SAMN04489866_10416	SAMN04489866_10641	Type I phosphodiesterase / nucleotide pyrophosphatase.	Arylsulfotransferase (ASST).	0.676
SDD52007.1	SDE04080.1	SAMN04489866_10416	SAMN04489866_11420	Type I phosphodiesterase / nucleotide pyrophosphatase.	Sodium:sulfate symporter transmembrane region.	0.496
SDD52007.1	SDE04117.1	SAMN04489866_10416	SAMN04489866_11421	Type I phosphodiesterase / nucleotide pyrophosphatase.	Arylsulfotransferase (ASST).	0.615
SDD66254.1	SDD12288.1	SAMN04489866_10573	SAMN04489866_101241	Di-and tricarboxylate transporter.	Nitrate reductase gamma subunit.	0.484
SDD66254.1	SDD52007.1	SAMN04489866_10573	SAMN04489866_10416	Di-and tricarboxylate transporter.	Type I phosphodiesterase / nucleotide pyrophosphatase.	0.510
SDD66254.1	SDD72535.1	SAMN04489866_10573	SAMN04489866_10641	Di-and tricarboxylate transporter.	Arylsulfotransferase (ASST).	0.770
SDD66254.1	SDD84409.1	SAMN04489866_10573	SAMN04489866_10857	Di-and tricarboxylate transporter.	Type I phosphodiesterase / nucleotide pyrophosphatase.	0.499

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Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.895

expected number of edges:

17

PPI enrichment p-value:

7.31e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009069

Serine family amino acid metabolic process

4 of 25

2.08

2.47

9.15e-06

GO:0006544

Glycine metabolic process

3 of 6

2.58

2.45

2.69e-05

GO:0019752

Carboxylic acid metabolic process

9 of 281

1.38

2.18

4.60e-09

GO:0006520

Cellular amino acid metabolic process

6 of 170

1.43

1.74

9.15e-06

GO:1901605

Alpha-amino acid metabolic process

5 of 123

1.49

1.63

5.61e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019842

Vitamin binding

3 of 51

1.65

0.86

0.0184

GO:0046872

Metal ion binding

6 of 555

0.91

0.57

0.0184

GO:0036094

Small molecule binding

6 of 819

0.74

0.42

0.0432

GO:0003824

Catalytic activity

11 of 3149

0.42

0.31

0.0184

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

5 of 319

1.07

0.87

0.0019

GO:0043231

Intracellular membrane-bounded organelle

3 of 96

1.37

0.86

0.0107

GO:0005737

Cytoplasm

10 of 1478

0.71

0.64

5.18e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:632

Mixed, incl. Carbon metabolism, and Valine, leucine and isoleucine biosynthesis

6 of 138

1.52

1.81

1.62e-05

CL:636

Mixed, incl. Citrate cycle (TCA cycle), and Alpha-amino acid catabolic process

4 of 48

1.8

1.64

0.00034

CL:880

Mixed, incl. FAD-linked oxidase-like, C-terminal, and Phosphoglycolate phosphatase-like, domain 2

2 of 10

2.18

0.85

0.0268

CL:705

Glycine metabolic process, and acetyl-CoA biosynthetic process from pyruvate

2 of 11

2.14

0.84

0.0271

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00260

Glycine, serine and threonine metabolism

3 of 35

1.81

1.34

0.0018

map01200

Carbon metabolism

4 of 136

1.35

1.09

0.0018

map01110

Biosynthesis of secondary metabolites

6 of 707

0.81

0.6

0.0040

map01100

Metabolic pathways

9 of 1973

0.54

0.41

0.0036

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

3 of 8

2.45

2.32

4.25e-05

GOCC:0009514

Glyoxysome

2 of 2

2.88

1.79

0.00057

GOCC:0005737

Cytoplasm

10 of 1152

0.82

0.8

8.02e-06

GOCC:0043231

Intracellular membrane-bounded organelle

4 of 247

1.09

0.71

0.0114

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00463

Isocitrate lyase family

2 of 2

2.88

1.18

0.0074

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039556

ICL/PEPM domain

2 of 2

2.88

0.97

0.0181

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