| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SBO16047.1 | SBO17534.1 | CDIV41_10018 | CDIV41_320095 | LPXTG-motif cell wall anchor domain protein (fragment). | Putative ComE operon protein 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.904 |
| SBO16047.1 | dut | CDIV41_10018 | CDIV41_270037 | LPXTG-motif cell wall anchor domain protein (fragment). | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
| SBO16047.1 | tdk | CDIV41_10018 | CDIV41_230045 | LPXTG-motif cell wall anchor domain protein (fragment). | Thymidine kinase/deoxyuridine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.903 |
| SBO16047.1 | thyB | CDIV41_10018 | CDIV41_320300 | LPXTG-motif cell wall anchor domain protein (fragment). | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.904 |
| SBO16047.1 | tmk | CDIV41_10018 | CDIV41_140012 | LPXTG-motif cell wall anchor domain protein (fragment). | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.910 |
| SBO17534.1 | SBO16047.1 | CDIV41_320095 | CDIV41_10018 | Putative ComE operon protein 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | LPXTG-motif cell wall anchor domain protein (fragment). | 0.904 |
| SBO17534.1 | dut | CDIV41_320095 | CDIV41_270037 | Putative ComE operon protein 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.946 |
| SBO17534.1 | tdk | CDIV41_320095 | CDIV41_230045 | Putative ComE operon protein 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Thymidine kinase/deoxyuridine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.931 |
| SBO17534.1 | thyB | CDIV41_320095 | CDIV41_320300 | Putative ComE operon protein 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.942 |
| SBO17534.1 | tmk | CDIV41_320095 | CDIV41_140012 | Putative ComE operon protein 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.931 |
| dfrA | folC | CDIV41_320301 | CDIV41_40010 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folyl-polyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | 0.926 |
| dfrA | glyA | CDIV41_320301 | CDIV41_230049 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
| dfrA | thyB | CDIV41_320301 | CDIV41_320300 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
| dut | SBO16047.1 | CDIV41_270037 | CDIV41_10018 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | LPXTG-motif cell wall anchor domain protein (fragment). | 0.900 |
| dut | SBO17534.1 | CDIV41_270037 | CDIV41_320095 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Putative ComE operon protein 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.946 |
| dut | tdk | CDIV41_270037 | CDIV41_230045 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase/deoxyuridine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.965 |
| dut | thyB | CDIV41_270037 | CDIV41_320300 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.965 |
| dut | tmk | CDIV41_270037 | CDIV41_140012 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.944 |
| folC | dfrA | CDIV41_40010 | CDIV41_320301 | Folyl-polyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.926 |
| folC | folD | CDIV41_40010 | CDIV41_40158 | Folyl-polyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.623 |