| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | clpP | CDIV41_320112 | CDIV41_120070 | Biotin/lipoate A/B ligase family protein (modular protein); Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.490 |
| birA | dnaK | CDIV41_320112 | CDIV41_320456 | Biotin/lipoate A/B ligase family protein (modular protein); Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.464 |
| birA | groES | CDIV41_320112 | CDIV41_100005 | Biotin/lipoate A/B ligase family protein (modular protein); Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Chaperonin small subunit; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.733 |
| birA | hrcA | CDIV41_320112 | CDIV41_320458 | Biotin/lipoate A/B ligase family protein (modular protein); Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Transcriptional regulator of heat-shock genes; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.639 |
| birA | lepA | CDIV41_320112 | CDIV41_320454 | Biotin/lipoate A/B ligase family protein (modular protein); Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Ribosomal elongation factor, GTPase; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.648 |
| clpP | birA | CDIV41_120070 | CDIV41_320112 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Biotin/lipoate A/B ligase family protein (modular protein); Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.490 |
| clpP | ctsR | CDIV41_120070 | CDIV41_140001 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Transcriptional regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CtsR family. | 0.620 |
| clpP | dnaJ | CDIV41_120070 | CDIV41_320455 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Co-factor of molecular chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 0.674 |
| clpP | dnaK | CDIV41_120070 | CDIV41_320456 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.715 |
| clpP | groEL | CDIV41_120070 | CDIV41_100004 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperonin large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.775 |
| clpP | groES | CDIV41_120070 | CDIV41_100005 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperonin small subunit; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.837 |
| clpP | grpE | CDIV41_120070 | CDIV41_320457 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.759 |
| clpP | hrcA | CDIV41_120070 | CDIV41_320458 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Transcriptional regulator of heat-shock genes; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.620 |
| ctsR | clpP | CDIV41_140001 | CDIV41_120070 | Transcriptional regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CtsR family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.620 |
| ctsR | dnaJ | CDIV41_140001 | CDIV41_320455 | Transcriptional regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CtsR family. | Co-factor of molecular chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 0.457 |
| ctsR | dnaK | CDIV41_140001 | CDIV41_320456 | Transcriptional regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CtsR family. | Molecular chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.604 |
| ctsR | groEL | CDIV41_140001 | CDIV41_100004 | Transcriptional regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CtsR family. | Chaperonin large subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.580 |
| ctsR | groES | CDIV41_140001 | CDIV41_100005 | Transcriptional regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CtsR family. | Chaperonin small subunit; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.701 |
| ctsR | grpE | CDIV41_140001 | CDIV41_320457 | Transcriptional regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CtsR family. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.576 |
| ctsR | hrcA | CDIV41_140001 | CDIV41_320458 | Transcriptional regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the CtsR family. | Transcriptional regulator of heat-shock genes; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.624 |
