EH55_12265 protein (Synergistes jonesii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EH55_12265

C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)

Predicted Functional Partners:

EH55_12270

0.921

EH55_02465

0.828

EH55_01490

0.825

EH55_11735

0.823

EH55_12710

0.816

EH55_12260

0.411

Your Current Organism:

Synergistes jonesii

NCBI taxonomy Id: 2754
Other names: ATCC 49833, S. jonesii, strain 78-1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.95

expected number of edges:

31

PPI enrichment p-value:

0.0955

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031929

TOR signaling

5 of 15

3.5

6.88

3.34e-13

GO:0006657

CDP-choline pathway

4 of 25

3.18

4.61

3.84e-09

GO:0006650

Glycerophospholipid metabolic process

6 of 568

2.0

3.49

1.45e-08

GO:0010506

Regulation of autophagy

3 of 24

3.08

3.19

1.55e-06

GO:0030307

Positive regulation of cell growth

3 of 32

2.95

3.04

2.78e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031210

Phosphatidylcholine binding

2 of 10

3.28

1.67

0.00098

GO:0004305

Ethanolamine kinase activity

2 of 12

3.2

1.67

0.00098

GO:0004105

Choline-phosphate cytidylyltransferase activity

2 of 7

3.44

1.67

0.00098

GO:0004103

Choline kinase activity

2 of 9

3.33

1.67

0.00098

GO:0008889

Glycerophosphodiester phosphodiesterase activity

2 of 38

2.7

1.41

0.0027

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031931

TORC1 complex

5 of 9

3.72

7.8

7.97e-15

GO:0031932

TORC2 complex

2 of 6

3.5

2.26

8.55e-05

GO:0110165

Cellular anatomical entity

9 of 19699

0.64

0.5

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17782

TOR complex, and Choline/ethanolamine kinase

5 of 13

3.57

6.76

5.71e-13

CL:106944

Phosphatidylcholine biosynthetic process

4 of 14

3.44

5.31

2.35e-10

CL:17798

TOR complex, and Choline/ethanolamine kinase

2 of 5

3.58

2.13

0.00015

CL:17784

TOR complex, and Choline/ethanolamine kinase

2 of 5

3.58

2.13

0.00015

CL:106961

Phosphoethanolamine N-methyltransferase, and Choline-phosphate cytidylyltransferase activity

2 of 5

3.58

2.13

0.00015

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04136

Autophagy - other

5 of 116

2.61

5.11

1.34e-10

map00564

Glycerophospholipid metabolism

6 of 919

1.79

3.09

1.60e-08

map00440

Phosphonate and phosphinate metabolism

2 of 29

2.82

1.98

0.00024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-166208

mTORC1-mediated signalling

5 of 10

3.68

7.71

1.14e-14

MAP-8943724

Regulation of PTEN gene transcription

5 of 32

3.17

6.57

8.26e-13

MAP-380972

Energy dependent regulation of mTOR by LKB1-AMPK

5 of 90

2.72

5.32

7.30e-11

MAP-165159

MTOR signalling

5 of 95

2.7

5.31

7.30e-11

MAP-9711097

Cellular response to starvation

5 of 109

2.64

5.17

1.11e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031931

TORC1 complex

5 of 18

3.42

6.93

2.42e-13

GOCC:0031932

TORC2 complex

2 of 15

3.1

1.73

0.00075

GOCC:0110165

Cellular anatomical entity

6 of 8339

0.84

0.48

0.0339

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

5 of 711

1.83

2.47

2.30e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01633

Choline/ethanolamine kinase

2 of 12

3.2

1.4

0.0030

PF01467

Cytidylyltransferase-like

2 of 25

2.88

1.24

0.0057

PF03009

Glycerophosphoryl diester phosphodiesterase family

2 of 38

2.7

1.14

0.0085

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029347

Raptor, N-terminal CASPase-like domain

3 of 3

3.98

3.78

1.61e-07

IPR004083

Regulatory associated protein of TOR

3 of 3

3.98

3.78

1.61e-07

IPR037588

Target of rapamycin complex subunit LST8

2 of 2

3.98

2.21

0.00011

IPR001680

WD40 repeat

5 of 765

1.8

2.04

2.92e-05

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

5 of 876

1.74

1.93

4.28e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01302

Raptor N-terminal CASPase like domain

3 of 3

3.98

4.43

1.12e-08

SM00320

WD40 repeats

5 of 771

1.79

2.38

3.18e-06

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About

node1	node2	node1 annotation	node2 annotation	score
EH55_01490	EH55_12260	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.817
EH55_01490	EH55_12265	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.825
EH55_02465	EH55_12260	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.819
EH55_02465	EH55_12265	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.828
EH55_11735	EH55_12260	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.816
EH55_11735	EH55_12265	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.823
EH55_12260	EH55_01490	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.817
EH55_12260	EH55_02465	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.819
EH55_12260	EH55_11735	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.816
EH55_12260	EH55_12265	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.411
EH55_12260	EH55_12270	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.870
EH55_12260	EH55_12710	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.811
EH55_12265	EH55_01490	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.825
EH55_12265	EH55_02465	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.828
EH55_12265	EH55_11735	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.823
EH55_12265	EH55_12260	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.411
EH55_12265	EH55_12270	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.921
EH55_12265	EH55_12710	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.816
EH55_12270	EH55_12260	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.870
EH55_12270	EH55_12265	C4-dicarboxylate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.921