KGQ22862.2 protein (Thermus filiformis) - STRING interaction network

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[Homology]

Score

KGQ22862.2

ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)

Predicted Functional Partners:

KGQ22864.1

0.999

grpE

0.923

groEL

0.913

groS

0.900

lon

0.797

lon-2

0.797

KGQ22863.2

0.778

hslO

0.741

clpX

0.738

dnaK

0.670

Your Current Organism:

Thermus filiformis

NCBI taxonomy Id: 276
Other names: ATCC 43280, DSM 4687, JCM 11600, T. filiformis, strain Wai33 A1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KGQ22862.2	KGQ22863.2	THFILI_02870	THFILI_02875	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	O-linked GlcNAc transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.778
KGQ22862.2	KGQ22864.1	THFILI_02870	THFILI_02865	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.999
KGQ22862.2	clpX	THFILI_02870	THFILI_06765	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Clp protease ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.738
KGQ22862.2	dnaK	THFILI_02870	THFILI_05300	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.670
KGQ22862.2	groEL	THFILI_02870	THFILI_04510	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.913
KGQ22862.2	groS	THFILI_02870	THFILI_04515	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.900
KGQ22862.2	grpE	THFILI_02870	THFILI_05305	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]	0.923
KGQ22862.2	hslO	THFILI_02870	THFILI_07095	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone Hsp33; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.	0.741
KGQ22862.2	lon	THFILI_02870	THFILI_02825	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.797
KGQ22862.2	lon-2	THFILI_02870	THFILI_09390	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.797
KGQ22863.2	KGQ22862.2	THFILI_02875	THFILI_02870	O-linked GlcNAc transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.778
KGQ22863.2	KGQ22864.1	THFILI_02875	THFILI_02865	O-linked GlcNAc transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.778
KGQ22863.2	dnaK	THFILI_02875	THFILI_05300	O-linked GlcNAc transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.632
KGQ22864.1	KGQ22862.2	THFILI_02865	THFILI_02870	ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	ATP-dependent protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KGQ22864.1	KGQ22863.2	THFILI_02865	THFILI_02875	ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	O-linked GlcNAc transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.778
KGQ22864.1	clpX	THFILI_02865	THFILI_06765	ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	Clp protease ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.632
KGQ22864.1	dnaK	THFILI_02865	THFILI_05300	ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.565
KGQ22864.1	groEL	THFILI_02865	THFILI_04510	ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.860
KGQ22864.1	groS	THFILI_02865	THFILI_04515	ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.885
KGQ22864.1	grpE	THFILI_02865	THFILI_05305	ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]	0.912