KGQ21249.2 protein (Thermus filiformis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Thermus filiformis

NCBI taxonomy Id: 276
Other names: ATCC 43280, DSM 4687, JCM 11600, T. filiformis, strain Wai33 A1

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KGQ21201.2	KGQ21249.2	THFILI_11620	THFILI_03285	Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	0.623
KGQ21248.1	KGQ21249.2	THFILI_03280	THFILI_03285	Phospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	0.821
KGQ21248.1	KGQ21251.2	THFILI_03280	THFILI_03275	Phospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.652
KGQ21249.2	KGQ21201.2	THFILI_03285	THFILI_11620	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.623
KGQ21249.2	KGQ21248.1	THFILI_03285	THFILI_03280	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	Phospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.821
KGQ21249.2	KGQ21251.2	THFILI_03285	THFILI_03275	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.633
KGQ21249.2	KGQ21634.1	THFILI_03285	THFILI_09185	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.545
KGQ21249.2	KGQ22612.1	THFILI_03285	THFILI_10300	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	Cell division protein; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.	0.764
KGQ21249.2	gyrA	THFILI_03285	THFILI_03345	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.523
KGQ21249.2	lepA	THFILI_03285	THFILI_03110	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	0.747
KGQ21249.2	rplY	THFILI_03285	THFILI_03450	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.	0.510
KGQ21249.2	secF	THFILI_03285	THFILI_00795	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	Preprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.	0.623
KGQ21249.2	topA	THFILI_03285	THFILI_04890	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.537
KGQ21251.2	KGQ21248.1	THFILI_03275	THFILI_03280	Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.652
KGQ21251.2	KGQ21249.2	THFILI_03275	THFILI_03285	Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	0.633
KGQ21634.1	KGQ21249.2	THFILI_09185	THFILI_03285	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	0.545
KGQ21634.1	lepA	THFILI_09185	THFILI_03110	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	0.677
KGQ21634.1	secF	THFILI_09185	THFILI_00795	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Preprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.	0.846
KGQ21634.1	topA	THFILI_09185	THFILI_04890	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.523
KGQ22612.1	KGQ21249.2	THFILI_10300	THFILI_03285	Cell division protein; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.	0.764