guaA protein (Thermus filiformis) - STRING interaction network

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Score

guaA

GMP synthase; Catalyzes the synthesis of GMP from XMP. (504 aa)

Predicted Functional Partners:

guaB

0.999

argS

0.996

rplK

0.994

KGQ22955.2

0.990

KGQ22953.1

0.990

pyrG

0.990

map

0.989

lysS

0.984

rplA

0.981

upp

0.980

Your Current Organism:

Thermus filiformis

NCBI taxonomy Id: 276
Other names: ATCC 43280, DSM 4687, JCM 11600, T. filiformis, strain Wai33 A1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KGQ22953.1	KGQ22955.2	THFILI_09005	THFILI_09000	Adenine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.978
KGQ22953.1	guaA	THFILI_09005	THFILI_03430	Adenine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.990
KGQ22953.1	guaB	THFILI_09005	THFILI_06055	Adenine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.770
KGQ22955.2	KGQ22953.1	THFILI_09000	THFILI_09005	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.978
KGQ22955.2	guaA	THFILI_09000	THFILI_03430	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.990
KGQ22955.2	guaB	THFILI_09000	THFILI_06055	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.	Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.770
argS	guaA	THFILI_08860	THFILI_03430	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.996
argS	lysS	THFILI_08860	THFILI_06805	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.898
argS	pyrG	THFILI_08860	THFILI_09150	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.857
argS	rplA	THFILI_08860	THFILI_05685	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.419
argS	rplK	THFILI_08860	THFILI_05690	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.528
guaA	KGQ22953.1	THFILI_03430	THFILI_09005	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Adenine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
guaA	KGQ22955.2	THFILI_03430	THFILI_09000	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
guaA	argS	THFILI_03430	THFILI_08860	GMP synthase; Catalyzes the synthesis of GMP from XMP.	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
guaA	guaB	THFILI_03430	THFILI_06055	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.999
guaA	lysS	THFILI_03430	THFILI_06805	GMP synthase; Catalyzes the synthesis of GMP from XMP.	lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.984
guaA	map	THFILI_03430	THFILI_10565	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	0.989
guaA	pyrG	THFILI_03430	THFILI_09150	GMP synthase; Catalyzes the synthesis of GMP from XMP.	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.990
guaA	rplA	THFILI_03430	THFILI_05685	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.981
guaA	rplK	THFILI_03430	THFILI_05690	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.994