Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KGQ22261.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)    
Predicted Functional Partners:
KIX84597.1
Abortive phage infection protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.683
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
  0.632
guaB
Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
  0.622
KGQ22956.2
Purine nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
  0.510
thyX
FAD-dependent thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
  0.479
KGQ22585.2
Nucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.472
KGQ21880.2
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.453
KGQ22123.2
Polya polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
    
  0.445
KIX84671.1
Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
  0.432
KGQ21593.1
Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
  0.431
Your Current Organism:
Thermus filiformis
NCBI taxonomy Id: 276
Other names: ATCC 43280, DSM 4687, JCM 11600, T. filiformis, strain Wai33 A1
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