thiI protein (Thermus filiformis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

thiI

Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (386 aa)

Predicted Functional Partners:

KGQ21582.2

0.946

KGQ22766.1

0.614

KGQ22933.2

0.543

KGQ21042.1

0.540

KGQ21847.1

0.532

KIX84757.1

0.516

mnmA

0.511

rny

0.477

KGQ23104.1

0.464

queA

0.451

Your Current Organism:

Thermus filiformis

NCBI taxonomy Id: 276
Other names: ATCC 43280, DSM 4687, JCM 11600, T. filiformis, strain Wai33 A1

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KGQ21042.1	thiI	THFILI_08605	THFILI_09100	rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.540
KGQ21582.2	KGQ22766.1	THFILI_02355	THFILI_07160	Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.781
KGQ21582.2	KIX84757.1	THFILI_02355	THFILI_02290	Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.916
KGQ21582.2	mnmA	THFILI_02355	THFILI_00295	Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.	0.634
KGQ21582.2	thiI	THFILI_02355	THFILI_09100	Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.946
KGQ21847.1	thiI	THFILI_01355	THFILI_09100	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.532
KGQ22766.1	KGQ21582.2	THFILI_07160	THFILI_02355	Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.781
KGQ22766.1	KIX84757.1	THFILI_07160	THFILI_02290	Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.715
KGQ22766.1	thiI	THFILI_07160	THFILI_09100	Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.614
KGQ22933.2	thiI	THFILI_09095	THFILI_09100	Permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.543
KGQ23104.1	thiI	THFILI_07225	THFILI_09100	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.464
KIX84757.1	KGQ21582.2	THFILI_02290	THFILI_02355	Adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.916
KIX84757.1	KGQ22766.1	THFILI_02290	THFILI_07160	Adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.715
KIX84757.1	thiI	THFILI_02290	THFILI_09100	Adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.516
mnmA	KGQ21582.2	THFILI_00295	THFILI_02355	Thiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.	Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.634
mnmA	rny	THFILI_00295	THFILI_06565	Thiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.	Ribonuclease; Endoribonuclease that initiates mRNA decay.	0.426
mnmA	thiI	THFILI_00295	THFILI_09100	Thiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.	Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.511
queA	rny	THFILI_07325	THFILI_06565	S-adenosylmethionine tRNA ribosyltransferase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).	Ribonuclease; Endoribonuclease that initiates mRNA decay.	0.525
queA	thiI	THFILI_07325	THFILI_09100	S-adenosylmethionine tRNA ribosyltransferase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).	Hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.451
rny	mnmA	THFILI_06565	THFILI_00295	Ribonuclease; Endoribonuclease that initiates mRNA decay.	Thiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.	0.426

page 1 of 2

Server load: low (8%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About