| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KGQ21321.2 | KGQ21516.1 | THFILI_00930 | THFILI_00990 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.994 |
| KGQ21321.2 | KIX84432.1 | THFILI_00930 | THFILI_11400 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.997 |
| KGQ21321.2 | mfd | THFILI_00930 | THFILI_07070 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.437 |
| KGQ21321.2 | mutL | THFILI_00930 | THFILI_10175 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.968 |
| KGQ21321.2 | mutS | THFILI_00930 | THFILI_10170 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.959 |
| KGQ21321.2 | mutS2 | THFILI_00930 | THFILI_04800 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Mannonate oxidoreductase; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. | 0.401 |
| KGQ21321.2 | polA | THFILI_00930 | THFILI_06865 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA polymerase I; Has 5'-3' exonuclease activity and no 3'-5' exonuclease activity. | 0.998 |
| KGQ21321.2 | recA | THFILI_00930 | THFILI_06570 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.987 |
| KGQ21321.2 | sbcD | THFILI_00930 | THFILI_09430 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.993 |
| KGQ21321.2 | topA | THFILI_00930 | THFILI_04890 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.991 |
| KGQ21516.1 | KGQ21321.2 | THFILI_00990 | THFILI_00930 | DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.994 |
| KGQ21516.1 | KIX84432.1 | THFILI_00990 | THFILI_11400 | DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.868 |
| KGQ21516.1 | mutL | THFILI_00990 | THFILI_10175 | DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.865 |
| KGQ21516.1 | polA | THFILI_00990 | THFILI_06865 | DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA polymerase I; Has 5'-3' exonuclease activity and no 3'-5' exonuclease activity. | 0.862 |
| KGQ21516.1 | recA | THFILI_00990 | THFILI_06570 | DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. | Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.876 |
| KGQ21516.1 | sbcD | THFILI_00990 | THFILI_09430 | DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.806 |
| KGQ21516.1 | topA | THFILI_00990 | THFILI_04890 | DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.886 |
| KIX84432.1 | KGQ21321.2 | THFILI_11400 | THFILI_00930 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.997 |
| KIX84432.1 | KGQ21516.1 | THFILI_11400 | THFILI_00990 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.868 |
| KIX84432.1 | mfd | THFILI_11400 | THFILI_07070 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.428 |
