ENSECRP00000000785 protein (Erpetoichthys calabaricus)

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second shell of interactors

Node Content

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ENSECRP00000000785

annotation not available (387 aa)

Predicted Functional Partners:

ENSECRP00000011256

0.634

nts

0.422

pnoc

0.415

haus3

0.415

haus8

0.411

pomc

0.410

haus1

0.405

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECRP00000000785	ENSECRP00000011256	ENSECRP00000000785	ENSECRP00000011256	annotation not available	annotation not available	0.634
ENSECRP00000000785	haus1	ENSECRP00000000785	ENSECRP00000026135	annotation not available	HAUS augmin like complex subunit 1.	0.405
ENSECRP00000000785	haus3	ENSECRP00000000785	ENSECRP00000029385	annotation not available	HAUS augmin like complex subunit 3.	0.415
ENSECRP00000000785	haus8	ENSECRP00000000785	ENSECRP00000030724	annotation not available	HAUS augmin like complex subunit 8.	0.411
ENSECRP00000000785	nts	ENSECRP00000000785	ENSECRP00000015873	annotation not available	Neurotensin.	0.422
ENSECRP00000000785	pnoc	ENSECRP00000000785	ENSECRP00000007023	annotation not available	Prepronociceptin.	0.415
ENSECRP00000000785	pomc	ENSECRP00000000785	ENSECRP00000008498	annotation not available	Proopiomelanocortin.	0.410
ENSECRP00000011256	ENSECRP00000000785	ENSECRP00000011256	ENSECRP00000000785	annotation not available	annotation not available	0.634
haus1	ENSECRP00000000785	ENSECRP00000026135	ENSECRP00000000785	HAUS augmin like complex subunit 1.	annotation not available	0.405
haus1	haus3	ENSECRP00000026135	ENSECRP00000029385	HAUS augmin like complex subunit 1.	HAUS augmin like complex subunit 3.	0.998
haus1	haus8	ENSECRP00000026135	ENSECRP00000030724	HAUS augmin like complex subunit 1.	HAUS augmin like complex subunit 8.	0.997
haus3	ENSECRP00000000785	ENSECRP00000029385	ENSECRP00000000785	HAUS augmin like complex subunit 3.	annotation not available	0.415
haus3	haus1	ENSECRP00000029385	ENSECRP00000026135	HAUS augmin like complex subunit 3.	HAUS augmin like complex subunit 1.	0.998
haus3	haus8	ENSECRP00000029385	ENSECRP00000030724	HAUS augmin like complex subunit 3.	HAUS augmin like complex subunit 8.	0.998
haus8	ENSECRP00000000785	ENSECRP00000030724	ENSECRP00000000785	HAUS augmin like complex subunit 8.	annotation not available	0.411
haus8	haus1	ENSECRP00000030724	ENSECRP00000026135	HAUS augmin like complex subunit 8.	HAUS augmin like complex subunit 1.	0.997
haus8	haus3	ENSECRP00000030724	ENSECRP00000029385	HAUS augmin like complex subunit 8.	HAUS augmin like complex subunit 3.	0.998
nts	ENSECRP00000000785	ENSECRP00000015873	ENSECRP00000000785	Neurotensin.	annotation not available	0.422
pnoc	ENSECRP00000000785	ENSECRP00000007023	ENSECRP00000000785	Prepronociceptin.	annotation not available	0.415
pnoc	pomc	ENSECRP00000007023	ENSECRP00000008498	Prepronociceptin.	Proopiomelanocortin.	0.906

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.889

expected number of edges:

11

PPI enrichment p-value:

0.172

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

4 of 32

1.76

1.43

0.0010

GO:0006635

Fatty acid beta-oxidation

2 of 6

2.18

0.86

0.0251

GO:0006631

Fatty acid metabolic process

3 of 51

1.43

0.74

0.0263

GO:0019538

Protein metabolic process

6 of 335

0.91

0.63

0.0087

GO:0044238

Primary metabolic process

9 of 1504

0.44

0.28

0.0488

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070403

NAD+ binding

3 of 5

2.44

1.83

0.00038

GO:0004673

Protein histidine kinase activity

4 of 33

1.74

1.59

0.00038

GO:0003857

3-hydroxyacyl-CoA dehydrogenase activity

2 of 3

2.48

1.16

0.0076

GO:0004300

enoyl-CoA hydratase activity

2 of 5

2.26

1.05

0.0113

GO:0016836

Hydro-lyase activity

3 of 59

1.37

0.74

0.0239

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3785

PAS domain, and Diguanylate cyclase

4 of 10

2.26

2.49

1.39e-05

CL:1810

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, and Thiolase, C-terminal domain

4 of 11

2.22

2.47

1.39e-05

CL:3789

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain), and Putative diguanylate phosphodiesterase

3 of 5

2.44

2.13

9.86e-05

CL:1812

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, and Thiolase, C-terminal domain

2 of 5

2.26

1.13

0.0080

CL:194

Structural constituent of ribosome

2 of 6

2.18

1.07

0.0099

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00650

Butanoate metabolism

5 of 52

1.64

2.05

8.71e-06

map00362

Benzoate degradation

3 of 51

1.43

0.94

0.0077

map01200

Carbon metabolism

5 of 197

1.07

0.84

0.0024

map00071

Fatty acid degradation

2 of 20

1.66

0.76

0.0314

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

4 of 58

1.5

1.22

0.0015

KW-0276

Fatty acid metabolism

2 of 16

1.76

0.73

0.0384

KW-0418

Kinase

4 of 135

1.13

0.68

0.0182

KW-0520

NAD

3 of 73

1.27

0.63

0.0384

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00725

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

3 of 4

2.54

1.99

0.00020

PF02737

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

2 of 2

2.66

1.11

0.0098

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

4 of 27

1.83

1.99

4.93e-05

SM00387

Histidine kinase-like ATPases

4 of 30

1.79

1.95

4.93e-05

SM00091

PAS domain

3 of 15

1.96

1.82

0.00020

SM00448

cheY-homologous receiver domain

4 of 41

1.65

1.76

7.66e-05

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 8

2.06

1.2

0.0051

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