LOC114667766 protein (Erpetoichthys calabaricus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

LOC114667766

Oocyte zinc finger protein XlCOF7.1-like. (337 aa)

Predicted Functional Partners:

ENSECRP00000011256

0.603

ENSECRP00000000849

0.527

ENSECRP00000031198

0.497

ythdc2

0.443

lamtor2

0.442

mrps11

0.438

LOC114656119

0.435

mrps9

0.434

mrps6

0.434

mrps16

0.434

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECRP00000000849	ENSECRP00000031198	ENSECRP00000000849	ENSECRP00000031198	annotation not available	annotation not available	0.527
ENSECRP00000000849	LOC114656119	ENSECRP00000000849	ENSECRP00000011369	annotation not available	Thioredoxin domain-containing protein 3 homolog.	0.931
ENSECRP00000000849	LOC114667766	ENSECRP00000000849	ENSECRP00000004178	annotation not available	Oocyte zinc finger protein XlCOF7.1-like.	0.527
ENSECRP00000000849	mrps11	ENSECRP00000000849	ENSECRP00000030286	annotation not available	Mitochondrial ribosomal protein S11.	0.604
ENSECRP00000000849	mrps9	ENSECRP00000000849	ENSECRP00000002034	annotation not available	Mitochondrial ribosomal protein S9.	0.603
ENSECRP00000011256	ENSECRP00000031198	ENSECRP00000011256	ENSECRP00000031198	annotation not available	annotation not available	0.603
ENSECRP00000011256	LOC114667766	ENSECRP00000011256	ENSECRP00000004178	annotation not available	Oocyte zinc finger protein XlCOF7.1-like.	0.603
ENSECRP00000031198	ENSECRP00000000849	ENSECRP00000031198	ENSECRP00000000849	annotation not available	annotation not available	0.527
ENSECRP00000031198	ENSECRP00000011256	ENSECRP00000031198	ENSECRP00000011256	annotation not available	annotation not available	0.603
ENSECRP00000031198	LOC114656119	ENSECRP00000031198	ENSECRP00000011369	annotation not available	Thioredoxin domain-containing protein 3 homolog.	0.435
ENSECRP00000031198	LOC114667766	ENSECRP00000031198	ENSECRP00000004178	annotation not available	Oocyte zinc finger protein XlCOF7.1-like.	0.497
ENSECRP00000031198	lamtor2	ENSECRP00000031198	ENSECRP00000004842	annotation not available	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	0.442
ENSECRP00000031198	mrps11	ENSECRP00000031198	ENSECRP00000030286	annotation not available	Mitochondrial ribosomal protein S11.	0.438
ENSECRP00000031198	mrps16	ENSECRP00000031198	ENSECRP00000009868	annotation not available	Mitochondrial ribosomal protein S16.	0.434
ENSECRP00000031198	mrps6	ENSECRP00000031198	ENSECRP00000003457	annotation not available	Mitochondrial ribosomal protein S6.	0.434
ENSECRP00000031198	mrps9	ENSECRP00000031198	ENSECRP00000002034	annotation not available	Mitochondrial ribosomal protein S9.	0.434
ENSECRP00000031198	ythdc2	ENSECRP00000031198	ENSECRP00000008197	annotation not available	YTH domain containing 2.	0.443
LOC114656119	ENSECRP00000000849	ENSECRP00000011369	ENSECRP00000000849	Thioredoxin domain-containing protein 3 homolog.	annotation not available	0.931
LOC114656119	ENSECRP00000031198	ENSECRP00000011369	ENSECRP00000031198	Thioredoxin domain-containing protein 3 homolog.	annotation not available	0.435
LOC114656119	LOC114667766	ENSECRP00000011369	ENSECRP00000004178	Thioredoxin domain-containing protein 3 homolog.	Oocyte zinc finger protein XlCOF7.1-like.	0.435

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.787

expected number of edges:

14

PPI enrichment p-value:

0.0197

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001963

Synaptic transmission, dopaminergic

3 of 14

2.59

1.81

0.00046

GO:0042417

Dopamine metabolic process

3 of 17

2.51

1.78

0.00051

GO:0098810

Neurotransmitter reuptake

3 of 18

2.48

1.77

0.00051

GO:0015844

Monoamine transport

3 of 18

2.48

1.77

0.00051

GO:0007212

Dopamine receptor signaling pathway

3 of 21

2.42

1.76

0.00051

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035240

Dopamine binding

3 of 6

2.96

2.48

3.07e-05

GO:0001591

Dopamine neurotransmitter receptor activity, coupled via Gi/Go

2 of 3

3.08

1.42

0.0027

GO:0015378

Sodium:chloride symporter activity

2 of 9

2.61

1.12

0.0090

GO:0008504

Monoamine transmembrane transporter activity

2 of 9

2.61

1.12

0.0090

GO:0005326

Neurotransmitter transmembrane transporter activity

2 of 14

2.42

1.04

0.0122

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

3 of 29

2.28

1.6

0.00094

GO:0036477

Somatodendritic compartment

5 of 589

1.19

0.87

0.0046

GO:0030425

Dendrite

4 of 436

1.22

0.8

0.0104

GO:0098797

Plasma membrane protein complex

4 of 456

1.2

0.79

0.0104

GO:0030424

Axon

4 of 477

1.18

0.78

0.0105

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26528222

(2015) Genetic influences on insight problem solving: the role of catechol-O-methyltransferase (COMT) gene polymorphisms.

3 of 5

3.04

2.56

2.23e-05

PMID:34072960

(2021) Understanding Emotions: Origins and Roles of the Amygdala.

3 of 12

2.66

2.19

9.02e-05

PMID:29579395

(2018) Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.

3 of 16

2.53

2.09

0.00013

PMID:33343403

(2020) The Autism Palette: Combinations of Impairments Explain the Heterogeneity in ASD.

2 of 6

2.78

1.22

0.0062

PMID:31616587

(2019) The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales.

2 of 6

2.78

1.22

0.0062

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:35990

Opioid Signalling, and Amine ligand-binding receptors

9 of 86

2.28

6.91

1.90e-16

CL:35991

Opioid Signalling, and Amine ligand-binding receptors

7 of 80

2.2

5.05

7.85e-12

CL:36005

Mixed, incl. Norepinephrine binding, and Mu-type opioid receptor binding

3 of 5

3.04

2.92

4.87e-06

CL:35999

G alpha (z) signalling events, and G-protein beta/gamma-subunit complex binding

4 of 35

2.32

2.81

3.40e-06

CL:36137

Dopamine receptors, and Response to gravity

3 of 7

2.89

2.79

7.83e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lav04726

Serotonergic synapse

4 of 94

1.89

2.01

5.73e-05

lav04728

Dopaminergic synapse

4 of 101

1.86

1.98

5.73e-05

lav04713

Circadian entrainment

3 of 75

1.86

1.48

0.0010

lav05032

Morphine addiction

3 of 79

1.84

1.47

0.0010

lav04727

GABAergic synapse

3 of 77

1.85

1.47

0.0010

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112311

Neurotransmitter clearance

3 of 9

2.78

2.53

2.30e-05

MAP-112315

Transmission across Chemical Synapses

6 of 261

1.62

2.12

3.93e-06

MAP-451326

Activation of kainate receptors upon glutamate binding

3 of 32

2.23

1.82

0.00034

MAP-4086398

Ca2+ pathway

3 of 41

2.12

1.68

0.00055

MAP-112316

Neuronal System

6 of 412

1.42

1.65

2.30e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0003954

Dopaminergic system

3 of 4

3.14

2.87

6.19e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

3 of 16

2.53

1.99

0.00020

GOCC:0071944

Cell periphery

9 of 4127

0.6

0.44

0.0051

GOCC:0005886

Plasma membrane

8 of 3874

0.58

0.36

0.0304

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0769

Symport

2 of 27

2.13

0.76

0.0383

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 4

2.96

0.86

0.0279

IPR001632

G-protein, beta subunit

2 of 6

2.78

0.86

0.0279

IPR000929

Dopamine receptor family

2 of 5

2.86

0.86

0.0279

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