hcn1 protein (Erpetoichthys calabaricus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

hcn1

Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (854 aa)

Predicted Functional Partners:

LOC114655412

0.607

LOC114664762

0.586

LOC114653135

0.585

LOC114649165

0.585

LOC114665876

0.492

tpcn1

0.492

nalcn

0.489

cacna1s

0.480

cacna1f

0.480

cacna1d

0.480

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC114649165	LOC114653135	ENSECRP00000016462	ENSECRP00000012743	Sodium channel protein type 8 subunit alpha-like.	Sodium channel protein type 4 subunit alpha-like.	0.933
LOC114649165	LOC114655412	ENSECRP00000016462	ENSECRP00000016269	Sodium channel protein type 8 subunit alpha-like.	Sodium channel protein type 2 subunit alpha-like.	0.934
LOC114649165	LOC114664762	ENSECRP00000016462	ENSECRP00000027079	Sodium channel protein type 8 subunit alpha-like.	Sodium channel protein type 4 subunit alpha A-like.	0.962
LOC114649165	hcn1	ENSECRP00000016462	ENSECRP00000004342	Sodium channel protein type 8 subunit alpha-like.	Hyperpolarization activated cyclic nucleotide gated potassium channel 1.	0.585
LOC114649165	nalcn	ENSECRP00000016462	ENSECRP00000019019	Sodium channel protein type 8 subunit alpha-like.	Sodium leak channel, non-selective.	0.443
LOC114653135	LOC114649165	ENSECRP00000012743	ENSECRP00000016462	Sodium channel protein type 4 subunit alpha-like.	Sodium channel protein type 8 subunit alpha-like.	0.933
LOC114653135	LOC114655412	ENSECRP00000012743	ENSECRP00000016269	Sodium channel protein type 4 subunit alpha-like.	Sodium channel protein type 2 subunit alpha-like.	0.933
LOC114653135	LOC114664762	ENSECRP00000012743	ENSECRP00000027079	Sodium channel protein type 4 subunit alpha-like.	Sodium channel protein type 4 subunit alpha A-like.	0.962
LOC114653135	hcn1	ENSECRP00000012743	ENSECRP00000004342	Sodium channel protein type 4 subunit alpha-like.	Hyperpolarization activated cyclic nucleotide gated potassium channel 1.	0.585
LOC114653135	nalcn	ENSECRP00000012743	ENSECRP00000019019	Sodium channel protein type 4 subunit alpha-like.	Sodium leak channel, non-selective.	0.443
LOC114655412	LOC114649165	ENSECRP00000016269	ENSECRP00000016462	Sodium channel protein type 2 subunit alpha-like.	Sodium channel protein type 8 subunit alpha-like.	0.934
LOC114655412	LOC114653135	ENSECRP00000016269	ENSECRP00000012743	Sodium channel protein type 2 subunit alpha-like.	Sodium channel protein type 4 subunit alpha-like.	0.933
LOC114655412	LOC114664762	ENSECRP00000016269	ENSECRP00000027079	Sodium channel protein type 2 subunit alpha-like.	Sodium channel protein type 4 subunit alpha A-like.	0.961
LOC114655412	hcn1	ENSECRP00000016269	ENSECRP00000004342	Sodium channel protein type 2 subunit alpha-like.	Hyperpolarization activated cyclic nucleotide gated potassium channel 1.	0.607
LOC114655412	nalcn	ENSECRP00000016269	ENSECRP00000019019	Sodium channel protein type 2 subunit alpha-like.	Sodium leak channel, non-selective.	0.479
LOC114664762	LOC114649165	ENSECRP00000027079	ENSECRP00000016462	Sodium channel protein type 4 subunit alpha A-like.	Sodium channel protein type 8 subunit alpha-like.	0.962
LOC114664762	LOC114653135	ENSECRP00000027079	ENSECRP00000012743	Sodium channel protein type 4 subunit alpha A-like.	Sodium channel protein type 4 subunit alpha-like.	0.962
LOC114664762	LOC114655412	ENSECRP00000027079	ENSECRP00000016269	Sodium channel protein type 4 subunit alpha A-like.	Sodium channel protein type 2 subunit alpha-like.	0.961
LOC114664762	hcn1	ENSECRP00000027079	ENSECRP00000004342	Sodium channel protein type 4 subunit alpha A-like.	Hyperpolarization activated cyclic nucleotide gated potassium channel 1.	0.586
LOC114664762	nalcn	ENSECRP00000027079	ENSECRP00000019019	Sodium channel protein type 4 subunit alpha A-like.	Sodium leak channel, non-selective.	0.420

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Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.882

expected number of edges:

11

PPI enrichment p-value:

1.09e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

9 of 352

0.85

0.8

5.26e-05

GO:0006810

Transport

10 of 438

0.8

0.75

4.65e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140359

ABC-type transporter activity

4 of 24

1.67

1.35

0.0012

GO:0015417

ABC-type polyamine transporter activity

3 of 9

1.97

1.33

0.0025

GO:0022857

Transmembrane transporter activity

6 of 325

0.71

0.4

0.0491

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

9 of 648

0.59

0.44

0.0039

GO:0016021

Integral component of membrane

9 of 749

0.52

0.4

0.0044

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4043

Mixed, incl. ABC-type polyamine transporter activity, and Sulfur metabolism

9 of 30

1.92

4.79

1.16e-13

CL:4045

ABC-type polyamine transporter activity, and Bacterial extracellular solute-binding protein

7 of 15

2.11

4.75

1.47e-11

CL:4047

ABC-type polyamine transporter activity, and ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

4 of 8

2.14

2.66

4.18e-06

CL:3850

Mixed, incl. ABC transporters, and beta-Lactam resistance

11 of 185

1.22

1.93

1.23e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

6 of 161

1.02

0.86

0.0010

map02024

Quorum sensing

4 of 96

1.06

0.66

0.0169

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

8 of 136

1.21

1.55

5.52e-07

KW-1003

Cell membrane

7 of 159

1.09

1.14

3.19e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

7 of 34

1.76

3.1

7.46e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035906

MetI-like superfamily

6 of 31

1.73

2.43

1.21e-06

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

6 of 31

1.73

2.43

1.21e-06

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