ENSECRP00000006275 protein (Erpetoichthys calabaricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSECRP00000006275

annotation not available (105 aa)

Predicted Functional Partners:

rbsn

0.990

stx16

0.989

vti1a

0.972

vti1b

0.959

stx6

0.933

stx10

0.933

ykt6

0.928

napb

0.912

LOC114668502

0.912

stx8

0.886

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECRP00000006275	LOC114668502	ENSECRP00000006275	ENSECRP00000033409	annotation not available	Alpha-soluble NSF attachment protein.	0.912
ENSECRP00000006275	napb	ENSECRP00000006275	ENSECRP00000024577	annotation not available	NSF attachment protein beta.	0.912
ENSECRP00000006275	rbsn	ENSECRP00000006275	ENSECRP00000028926	annotation not available	Rabenosyn, RAB effector.	0.990
ENSECRP00000006275	stx10	ENSECRP00000006275	ENSECRP00000024966	annotation not available	Syntaxin 10.	0.933
ENSECRP00000006275	stx16	ENSECRP00000006275	ENSECRP00000012584	annotation not available	Syntaxin 16.	0.989
ENSECRP00000006275	stx6	ENSECRP00000006275	ENSECRP00000012059	annotation not available	Syntaxin 6.	0.933
ENSECRP00000006275	stx8	ENSECRP00000006275	ENSECRP00000031333	annotation not available	Syntaxin 8.	0.886
ENSECRP00000006275	vti1a	ENSECRP00000006275	ENSECRP00000009001	annotation not available	Vesicle transport through interaction with t-SNAREs 1A.	0.972
ENSECRP00000006275	vti1b	ENSECRP00000006275	ENSECRP00000027912	annotation not available	Vesicle transport through interaction with t-SNAREs 1B.	0.959
ENSECRP00000006275	ykt6	ENSECRP00000006275	ENSECRP00000000560	annotation not available	YKT6 v-SNARE homolog.	0.928
LOC114668502	ENSECRP00000006275	ENSECRP00000033409	ENSECRP00000006275	Alpha-soluble NSF attachment protein.	annotation not available	0.912
LOC114668502	stx10	ENSECRP00000033409	ENSECRP00000024966	Alpha-soluble NSF attachment protein.	Syntaxin 10.	0.948
LOC114668502	stx16	ENSECRP00000033409	ENSECRP00000012584	Alpha-soluble NSF attachment protein.	Syntaxin 16.	0.974
LOC114668502	stx6	ENSECRP00000033409	ENSECRP00000012059	Alpha-soluble NSF attachment protein.	Syntaxin 6.	0.948
LOC114668502	stx8	ENSECRP00000033409	ENSECRP00000031333	Alpha-soluble NSF attachment protein.	Syntaxin 8.	0.957
LOC114668502	vti1a	ENSECRP00000033409	ENSECRP00000009001	Alpha-soluble NSF attachment protein.	Vesicle transport through interaction with t-SNAREs 1A.	0.988
LOC114668502	vti1b	ENSECRP00000033409	ENSECRP00000027912	Alpha-soluble NSF attachment protein.	Vesicle transport through interaction with t-SNAREs 1B.	0.969
LOC114668502	ykt6	ENSECRP00000033409	ENSECRP00000000560	Alpha-soluble NSF attachment protein.	YKT6 v-SNARE homolog.	0.974
napb	ENSECRP00000006275	ENSECRP00000024577	ENSECRP00000006275	NSF attachment protein beta.	annotation not available	0.912
napb	stx10	ENSECRP00000024577	ENSECRP00000024966	NSF attachment protein beta.	Syntaxin 10.	0.948

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

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