prcp protein (Erpetoichthys calabaricus) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

prcp

Prolylcarboxypeptidase. (542 aa)

Predicted Functional Partners:

ENSECRP00000008400

0.853

xpnpep1

0.734

xpnpep2

0.734

ENSECRP00000012783

0.725

ENSECRP00000012809

0.725

LOC114649286

0.725

mmel1

0.715

mme

0.715

ENSECRP00000009840

0.710

gcg

0.710

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECRP00000008400	ENSECRP00000009840	ENSECRP00000008400	ENSECRP00000009840	annotation not available	annotation not available	0.850
ENSECRP00000008400	ENSECRP00000012783	ENSECRP00000008400	ENSECRP00000012783	annotation not available	annotation not available	0.770
ENSECRP00000008400	ENSECRP00000012809	ENSECRP00000008400	ENSECRP00000012809	annotation not available	annotation not available	0.766
ENSECRP00000008400	LOC114649286	ENSECRP00000008400	ENSECRP00000012870	annotation not available	Meprin A subunit alpha-like.	0.770
ENSECRP00000008400	gcg	ENSECRP00000008400	ENSECRP00000010094	annotation not available	Glucagon.	0.831
ENSECRP00000008400	mme	ENSECRP00000008400	ENSECRP00000010742	annotation not available	Membrane metalloendopeptidase.	0.850
ENSECRP00000008400	mmel1	ENSECRP00000008400	ENSECRP00000009193	annotation not available	Membrane metalloendopeptidase like 1.	0.850
ENSECRP00000008400	prcp	ENSECRP00000008400	ENSECRP00000013896	annotation not available	Prolylcarboxypeptidase.	0.853
ENSECRP00000008400	xpnpep1	ENSECRP00000008400	ENSECRP00000009749	annotation not available	X-prolyl aminopeptidase 1.	0.832
ENSECRP00000008400	xpnpep2	ENSECRP00000008400	ENSECRP00000018630	annotation not available	X-prolyl aminopeptidase 2.	0.832
ENSECRP00000009840	ENSECRP00000008400	ENSECRP00000009840	ENSECRP00000008400	annotation not available	annotation not available	0.850
ENSECRP00000009840	ENSECRP00000012783	ENSECRP00000009840	ENSECRP00000012783	annotation not available	annotation not available	0.647
ENSECRP00000009840	ENSECRP00000012809	ENSECRP00000009840	ENSECRP00000012809	annotation not available	annotation not available	0.647
ENSECRP00000009840	LOC114649286	ENSECRP00000009840	ENSECRP00000012870	annotation not available	Meprin A subunit alpha-like.	0.647
ENSECRP00000009840	mme	ENSECRP00000009840	ENSECRP00000010742	annotation not available	Membrane metalloendopeptidase.	0.721
ENSECRP00000009840	mmel1	ENSECRP00000009840	ENSECRP00000009193	annotation not available	Membrane metalloendopeptidase like 1.	0.734
ENSECRP00000009840	prcp	ENSECRP00000009840	ENSECRP00000013896	annotation not available	Prolylcarboxypeptidase.	0.710
ENSECRP00000009840	xpnpep1	ENSECRP00000009840	ENSECRP00000009749	annotation not available	X-prolyl aminopeptidase 1.	0.732
ENSECRP00000009840	xpnpep2	ENSECRP00000009840	ENSECRP00000018630	annotation not available	X-prolyl aminopeptidase 2.	0.732
ENSECRP00000012783	ENSECRP00000008400	ENSECRP00000012783	ENSECRP00000008400	annotation not available	annotation not available	0.770

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.687

expected number of edges:

18

PPI enrichment p-value:

0.0101

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006865

Amino acid transport

5 of 49

1.86

2.28

9.20e-06

GO:0015803

Branched-chain amino acid transport

2 of 2

2.85

1.37

0.0033

GO:0003333

Amino acid transmembrane transport

2 of 8

2.24

0.91

0.0206

GO:0000160

Phosphorelay signal transduction system

4 of 219

1.11

0.61

0.0315

GO:0006810

Transport

6 of 718

0.77

0.46

0.0315

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

4 of 116

1.38

0.82

0.0148

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009274

Peptidoglycan-based cell wall

4 of 302

0.97

0.55

0.0314

GO:0005886

Plasma membrane

9 of 1854

0.53

0.37

0.0134

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9153

Mixed, incl. Leucine-binding protein domain, and ANTAR domain

10 of 13

2.73

10.83

1.00e-22

CL:9168

Branched-chain amino acid transport, and Leucine-binding protein domain

5 of 5

2.85

5.17

2.13e-10

CL:9155

ANTAR domain, and Leucine-binding protein domain

3 of 5

2.63

2.37

4.04e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

6 of 380

1.05

0.9

0.00080

map02024

Quorum sensing

5 of 302

1.07

0.83

0.0026

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005561

ANTAR domain

3 of 5

2.63

1.95

0.00026

IPR029016

GAF-like domain superfamily

4 of 34

1.92

1.75

0.00026

IPR003018

GAF domain

3 of 16

2.12

1.47

0.0015

IPR028081

Leucine-binding protein domain

2 of 3

2.67

1.1

0.0101

IPR012074

GAF-ANTAR transcription anti-termination regulator, putative

2 of 3

2.67

1.1

0.0101

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01012

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.

3 of 5

2.63

2.68

1.02e-05

SM00065

Domain present in phytochromes and cGMP-specific phosphodiesterases.

4 of 22

2.11

2.58

5.57e-06

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