rbbp8nl protein (Erpetoichthys calabaricus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

rbbp8nl

RBBP8 N-terminal like. (619 aa)

Predicted Functional Partners:

cdk5

0.817

ENSECRP00000007787

0.639

ccne2

0.639

ccna1

0.618

ccna2

0.618

cdk1

0.562

ENSECRP00000016719

0.562

cdk4

0.562

cdk2

0.562

cdk6

0.562

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECRP00000007787	ENSECRP00000016719	ENSECRP00000007787	ENSECRP00000016719	annotation not available	annotation not available	0.884
ENSECRP00000007787	ccna1	ENSECRP00000007787	ENSECRP00000001211	annotation not available	Cyclin A1.	0.884
ENSECRP00000007787	ccna2	ENSECRP00000007787	ENSECRP00000014484	annotation not available	Cyclin A2.	0.882
ENSECRP00000007787	ccne2	ENSECRP00000007787	ENSECRP00000024656	annotation not available	Cyclin E2.	0.848
ENSECRP00000007787	cdk1	ENSECRP00000007787	ENSECRP00000002542	annotation not available	Cyclin dependent kinase 1.	0.900
ENSECRP00000007787	cdk2	ENSECRP00000007787	ENSECRP00000020242	annotation not available	Cyclin dependent kinase 2.	0.975
ENSECRP00000007787	cdk4	ENSECRP00000007787	ENSECRP00000016726	annotation not available	Cyclin dependent kinase 4.	0.884
ENSECRP00000007787	cdk5	ENSECRP00000007787	ENSECRP00000001258	annotation not available	Cyclin dependent kinase 5.	0.671
ENSECRP00000007787	cdk6	ENSECRP00000007787	ENSECRP00000020970	annotation not available	Cyclin dependent kinase 6.	0.899
ENSECRP00000007787	rbbp8nl	ENSECRP00000007787	ENSECRP00000016596	annotation not available	RBBP8 N-terminal like.	0.639
ENSECRP00000016719	ENSECRP00000007787	ENSECRP00000016719	ENSECRP00000007787	annotation not available	annotation not available	0.884
ENSECRP00000016719	ccna1	ENSECRP00000016719	ENSECRP00000001211	annotation not available	Cyclin A1.	0.925
ENSECRP00000016719	ccna2	ENSECRP00000016719	ENSECRP00000014484	annotation not available	Cyclin A2.	0.924
ENSECRP00000016719	ccne2	ENSECRP00000016719	ENSECRP00000024656	annotation not available	Cyclin E2.	0.884
ENSECRP00000016719	cdk5	ENSECRP00000016719	ENSECRP00000001258	annotation not available	Cyclin dependent kinase 5.	0.533
ENSECRP00000016719	rbbp8nl	ENSECRP00000016719	ENSECRP00000016596	annotation not available	RBBP8 N-terminal like.	0.562
ccna1	ENSECRP00000007787	ENSECRP00000001211	ENSECRP00000007787	Cyclin A1.	annotation not available	0.884
ccna1	ENSECRP00000016719	ENSECRP00000001211	ENSECRP00000016719	Cyclin A1.	annotation not available	0.925
ccna1	ccna2	ENSECRP00000001211	ENSECRP00000014484	Cyclin A1.	Cyclin A2.	0.848
ccna1	ccne2	ENSECRP00000001211	ENSECRP00000024656	Cyclin A1.	Cyclin E2.	0.883

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

2.95e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 328

1.8

4.86

1.46e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 159

2.07

6.34

2.75e-17

GO:0019843

rRNA binding

3 of 51

2.05

1.36

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 184

2.01

5.98

5.37e-17

GO:0044391

Ribosomal subunit

4 of 135

1.75

1.71

0.00019

GO:0015935

Small ribosomal subunit

3 of 46

2.09

1.69

0.00050

GO:0022627

Cytosolic small ribosomal subunit

2 of 18

2.32

1.12

0.0086

GO:1990904

Ribonucleoprotein complex

5 of 555

1.23

1.04

0.0012

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28942070

(2017) Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison.

2 of 9

2.62

0.93

0.0209

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15235