ENSECRP00000023634 protein (Erpetoichthys calabaricus)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSECRP00000023634

annotation not available (100 aa)

Predicted Functional Partners:

dynlt3

0.871

dnai2

0.865

LOC114664422

0.865

dynlt1

0.851

LOC114664657

0.851

dync2li1

0.837

ENSECRP00000012954

0.826

dynlrb1

0.826

ENSECRP00000015505

0.826

dynlrb2

0.826

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECRP00000012954	ENSECRP00000023634	ENSECRP00000012954	ENSECRP00000023634	annotation not available	annotation not available	0.826
ENSECRP00000012954	LOC114664422	ENSECRP00000012954	ENSECRP00000026434	annotation not available	Dynein intermediate chain 2, axonemal-like.	0.776
ENSECRP00000012954	LOC114664657	ENSECRP00000012954	ENSECRP00000017055	annotation not available	Dynein light chain Tctex-type 1-like.	0.882
ENSECRP00000012954	dnai2	ENSECRP00000012954	ENSECRP00000026208	annotation not available	Dynein axonemal intermediate chain 2.	0.776
ENSECRP00000012954	dync2li1	ENSECRP00000012954	ENSECRP00000022896	annotation not available	Dynein cytoplasmic 2 light intermediate chain 1.	0.916
ENSECRP00000012954	dynlt1	ENSECRP00000012954	ENSECRP00000004332	annotation not available	Dynein light chain Tctex-type 1.	0.907
ENSECRP00000012954	dynlt3	ENSECRP00000012954	ENSECRP00000001669	annotation not available	Dynein light chain Tctex-type 3.	0.924
ENSECRP00000015505	ENSECRP00000023634	ENSECRP00000015505	ENSECRP00000023634	annotation not available	annotation not available	0.826
ENSECRP00000015505	LOC114664422	ENSECRP00000015505	ENSECRP00000026434	annotation not available	Dynein intermediate chain 2, axonemal-like.	0.776
ENSECRP00000015505	LOC114664657	ENSECRP00000015505	ENSECRP00000017055	annotation not available	Dynein light chain Tctex-type 1-like.	0.882
ENSECRP00000015505	dnai2	ENSECRP00000015505	ENSECRP00000026208	annotation not available	Dynein axonemal intermediate chain 2.	0.776
ENSECRP00000015505	dync2li1	ENSECRP00000015505	ENSECRP00000022896	annotation not available	Dynein cytoplasmic 2 light intermediate chain 1.	0.916
ENSECRP00000015505	dynlt1	ENSECRP00000015505	ENSECRP00000004332	annotation not available	Dynein light chain Tctex-type 1.	0.907
ENSECRP00000015505	dynlt3	ENSECRP00000015505	ENSECRP00000001669	annotation not available	Dynein light chain Tctex-type 3.	0.924
ENSECRP00000023634	ENSECRP00000012954	ENSECRP00000023634	ENSECRP00000012954	annotation not available	annotation not available	0.826
ENSECRP00000023634	ENSECRP00000015505	ENSECRP00000023634	ENSECRP00000015505	annotation not available	annotation not available	0.826
ENSECRP00000023634	LOC114664422	ENSECRP00000023634	ENSECRP00000026434	annotation not available	Dynein intermediate chain 2, axonemal-like.	0.865
ENSECRP00000023634	LOC114664657	ENSECRP00000023634	ENSECRP00000017055	annotation not available	Dynein light chain Tctex-type 1-like.	0.851
ENSECRP00000023634	dnai2	ENSECRP00000023634	ENSECRP00000026208	annotation not available	Dynein axonemal intermediate chain 2.	0.865
ENSECRP00000023634	dync2li1	ENSECRP00000023634	ENSECRP00000022896	annotation not available	Dynein cytoplasmic 2 light intermediate chain 1.	0.837

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.354

expected number of edges:

14

PPI enrichment p-value:

1.77e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007189

Adenylate cyclase-activating G protein-coupled receptor signaling pathway

5 of 113

1.9

2.23

1.69e-05

GO:0007186

G protein-coupled receptor signaling pathway

11 of 1117

1.25

1.94

2.11e-10

GO:0007212

Dopamine receptor signaling pathway

3 of 21

2.41

1.82

0.00040

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

2 of 7

2.71

1.19

0.0069

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030159

Signaling receptor complex adaptor activity

4 of 39

2.27

2.43

1.89e-05

GO:0031683

G-protein beta/gamma-subunit complex binding

2 of 22

2.21

0.77

0.0387

GO:0044877

Protein-containing complex binding

6 of 1127

0.98

0.64

0.0124

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

7 of 33

2.58

6.71

3.94e-14

GO:0005886

Plasma membrane

11 of 4790

0.62

0.55

2.55e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:33829

Mixed, incl. Heterotrimeric G-protein complex, and The phototransduction cascade

6 of 94

2.06

3.47

2.76e-08

CL:33835

Mixed, incl. G beta:gamma signalling through PLC beta, and Dopamine receptor signaling pathway

4 of 32

2.35

2.88

2.59e-06

CL:20896

Latrophilin Cytoplasmic C-terminal region, and GHH signature containing HNH/Endo VII superfamily nuclease toxin

3 of 6

2.95

2.86

6.08e-06

CL:33837

G beta:gamma signalling through PLC beta, and Dopamine receptor signaling pathway

3 of 21

2.41

2.12

0.00010

CL:33839

Adrenaline,noradrenaline inhibits insulin secretion, and G protein-coupled serotonin receptor binding

2 of 11

2.52

1.2

0.0063

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pcw04728

Dopaminergic synapse

5 of 114

1.9

2.67

1.06e-06

pcw04727

GABAergic synapse

4 of 77

1.97

2.32

1.38e-05

pcw05032

Morphine addiction

4 of 82

1.94

2.3

1.38e-05

pcw04713

Circadian entrainment

4 of 86

1.92

2.28

1.38e-05

pcw04726

Serotonergic synapse

4 of 93

1.89

2.25

1.38e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-373080

Class B/2 (Secretin family receptors)

8 of 61

2.37

6.7

3.91e-15

MAP-8964315

G beta:gamma signalling through BTK

6 of 18

2.78

6.47

4.14e-13

MAP-8964616

G beta:gamma signalling through CDC42

6 of 19

2.76

6.45

4.14e-13

MAP-418217

G beta:gamma signalling through PLC beta

6 of 20

2.73

6.42

4.25e-13

MAP-500657

Presynaptic function of Kainate receptors

6 of 21

2.71

6.39

4.55e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

7 of 17

2.87

7.9

7.88e-16

GOCC:0005886

Plasma membrane

9 of 2573

0.8

0.73

6.85e-05

GOCC:0016020

Membrane

10 of 4798

0.57

0.47

0.00071

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

5 of 282

1.5

1.58

0.00010

KW-0807

Transducer

6 of 839

1.11

1.01

0.00045

KW-0677

Repeat

5 of 1247

0.86

0.47

0.0440

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02354

Latrophilin Cytoplasmic C-terminal region

3 of 3

3.26

2.9

5.77e-06

PF02140

Galactose binding lectin domain

3 of 5

3.03

2.8

8.08e-06

PF16489

GPCR-Autoproteolysis INducing (GAIN) domain

3 of 10

2.73

2.48

2.75e-05

PF00002

7 transmembrane receptor (Secretin family)

3 of 47

2.06

1.47

0.0014

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00284

Olfactomedin-like domains

3 of 13

2.62

2.3

5.59e-05

SM00303

G-protein-coupled receptor proteolytic site domain

3 of 28

2.29

2.0

0.00015

SM00320

WD40 repeats

5 of 276

1.51

1.6

9.37e-05

SM00275

G protein alpha subunit

2 of 16

2.35

1.12

0.0084

SM00008

Domain present in hormone receptors

2 of 19

2.28

1.1

0.0092

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