ENSECRP00000023760 protein (Erpetoichthys calabaricus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSECRP00000023760

annotation not available (510 aa)

Predicted Functional Partners:

hcfc1

0.957

hcfc2

0.957

mcrs1

0.870

arid4a

0.868

arid4b

0.868

kansl2

0.867

tex30

0.858

kansl3

0.858

uchl5

0.837

bap1

0.837

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECRP00000023760	arid4a	ENSECRP00000023760	ENSECRP00000023529	annotation not available	AT-rich interaction domain 4A.	0.868
ENSECRP00000023760	arid4b	ENSECRP00000023760	ENSECRP00000025145	annotation not available	AT-rich interaction domain 4B.	0.868
ENSECRP00000023760	bap1	ENSECRP00000023760	ENSECRP00000029725	annotation not available	BRCA1 associated protein 1.	0.837
ENSECRP00000023760	hcfc1	ENSECRP00000023760	ENSECRP00000011745	annotation not available	Host cell factor C1.	0.957
ENSECRP00000023760	hcfc2	ENSECRP00000023760	ENSECRP00000016577	annotation not available	Host cell factor C2.	0.957
ENSECRP00000023760	kansl2	ENSECRP00000023760	ENSECRP00000015772	annotation not available	KAT8 regulatory NSL complex subunit 2.	0.867
ENSECRP00000023760	kansl3	ENSECRP00000023760	ENSECRP00000011163	annotation not available	KAT8 regulatory NSL complex subunit 3.	0.858
ENSECRP00000023760	mcrs1	ENSECRP00000023760	ENSECRP00000019747	annotation not available	Microspherule protein 1.	0.870
ENSECRP00000023760	tex30	ENSECRP00000023760	ENSECRP00000008356	annotation not available	Testis expressed 30.	0.858
ENSECRP00000023760	uchl5	ENSECRP00000023760	ENSECRP00000017550	annotation not available	Ubiquitin C-terminal hydrolase L5.	0.837
arid4a	ENSECRP00000023760	ENSECRP00000023529	ENSECRP00000023760	AT-rich interaction domain 4A.	annotation not available	0.868
arid4a	arid4b	ENSECRP00000023529	ENSECRP00000025145	AT-rich interaction domain 4A.	AT-rich interaction domain 4B.	0.770
arid4a	hcfc1	ENSECRP00000023529	ENSECRP00000011745	AT-rich interaction domain 4A.	Host cell factor C1.	0.618
arid4a	hcfc2	ENSECRP00000023529	ENSECRP00000016577	AT-rich interaction domain 4A.	Host cell factor C2.	0.618
arid4a	kansl2	ENSECRP00000023529	ENSECRP00000015772	AT-rich interaction domain 4A.	KAT8 regulatory NSL complex subunit 2.	0.752
arid4a	kansl3	ENSECRP00000023529	ENSECRP00000011163	AT-rich interaction domain 4A.	KAT8 regulatory NSL complex subunit 3.	0.627
arid4a	mcrs1	ENSECRP00000023529	ENSECRP00000019747	AT-rich interaction domain 4A.	Microspherule protein 1.	0.755
arid4a	tex30	ENSECRP00000023529	ENSECRP00000008356	AT-rich interaction domain 4A.	Testis expressed 30.	0.627
arid4b	ENSECRP00000023760	ENSECRP00000025145	ENSECRP00000023760	AT-rich interaction domain 4B.	annotation not available	0.868
arid4b	arid4a	ENSECRP00000025145	ENSECRP00000023529	AT-rich interaction domain 4B.	AT-rich interaction domain 4A.	0.770

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

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