sergef protein (Erpetoichthys calabaricus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

sergef

Secretion regulating guanine nucleotide exchange factor. (332 aa)

Predicted Functional Partners:

dph3

0.988

LOC114650950

0.716

zfand4

0.633

LOC114659684

0.623

adgrb2

0.623

ENSECRP00000027118

0.623

adgrb1

0.623

ran

0.623

ENSECRP00000029575

0.623

rbpj

0.601

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECRP00000027118	LOC114650950	ENSECRP00000027118	ENSECRP00000019131	annotation not available	E3 SUMO-protein ligase RanBP2-like.	0.991
ENSECRP00000027118	sergef	ENSECRP00000027118	ENSECRP00000029929	annotation not available	Secretion regulating guanine nucleotide exchange factor.	0.623
ENSECRP00000029575	LOC114650950	ENSECRP00000029575	ENSECRP00000019131	annotation not available	E3 SUMO-protein ligase RanBP2-like.	0.992
ENSECRP00000029575	sergef	ENSECRP00000029575	ENSECRP00000029929	annotation not available	Secretion regulating guanine nucleotide exchange factor.	0.623
LOC114650950	ENSECRP00000027118	ENSECRP00000019131	ENSECRP00000027118	E3 SUMO-protein ligase RanBP2-like.	annotation not available	0.991
LOC114650950	ENSECRP00000029575	ENSECRP00000019131	ENSECRP00000029575	E3 SUMO-protein ligase RanBP2-like.	annotation not available	0.992
LOC114650950	LOC114659684	ENSECRP00000019131	ENSECRP00000015504	E3 SUMO-protein ligase RanBP2-like.	GTP-binding nuclear protein Ran.	0.992
LOC114650950	adgrb1	ENSECRP00000019131	ENSECRP00000027361	E3 SUMO-protein ligase RanBP2-like.	Adhesion G protein-coupled receptor B1.	0.991
LOC114650950	adgrb2	ENSECRP00000019131	ENSECRP00000019276	E3 SUMO-protein ligase RanBP2-like.	Adhesion G protein-coupled receptor B2.	0.991
LOC114650950	ran	ENSECRP00000019131	ENSECRP00000029533	E3 SUMO-protein ligase RanBP2-like.	RAN, member RAS oncogene family.	0.992
LOC114650950	sergef	ENSECRP00000019131	ENSECRP00000029929	E3 SUMO-protein ligase RanBP2-like.	Secretion regulating guanine nucleotide exchange factor.	0.716
LOC114659684	LOC114650950	ENSECRP00000015504	ENSECRP00000019131	GTP-binding nuclear protein Ran.	E3 SUMO-protein ligase RanBP2-like.	0.992
LOC114659684	sergef	ENSECRP00000015504	ENSECRP00000029929	GTP-binding nuclear protein Ran.	Secretion regulating guanine nucleotide exchange factor.	0.623
adgrb1	LOC114650950	ENSECRP00000027361	ENSECRP00000019131	Adhesion G protein-coupled receptor B1.	E3 SUMO-protein ligase RanBP2-like.	0.991
adgrb1	sergef	ENSECRP00000027361	ENSECRP00000029929	Adhesion G protein-coupled receptor B1.	Secretion regulating guanine nucleotide exchange factor.	0.623
adgrb2	LOC114650950	ENSECRP00000019276	ENSECRP00000019131	Adhesion G protein-coupled receptor B2.	E3 SUMO-protein ligase RanBP2-like.	0.991
adgrb2	sergef	ENSECRP00000019276	ENSECRP00000029929	Adhesion G protein-coupled receptor B2.	Secretion regulating guanine nucleotide exchange factor.	0.623
dph3	sergef	ENSECRP00000002196	ENSECRP00000029929	Diphthamide biosynthesis 3.	Secretion regulating guanine nucleotide exchange factor.	0.988
ran	LOC114650950	ENSECRP00000029533	ENSECRP00000019131	RAN, member RAS oncogene family.	E3 SUMO-protein ligase RanBP2-like.	0.992
ran	sergef	ENSECRP00000029533	ENSECRP00000029929	RAN, member RAS oncogene family.	Secretion regulating guanine nucleotide exchange factor.	0.623

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.919

expected number of edges:

11

PPI enrichment p-value:

3.44e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032784

Regulation of DNA-templated transcription, elongation

7 of 21

2.45

5.84

1.21e-12

GO:0032786

Positive regulation of DNA-templated transcription, elongation

5 of 17

2.39

4.02

1.09e-08

GO:0006355

Regulation of transcription, DNA-templated

10 of 482

1.24

1.82

3.13e-09

GO:0006357

Regulation of transcription by RNA polymerase II

8 of 338

1.3

1.8

1.26e-07

GO:0006368

Transcription elongation from RNA polymerase II promoter

3 of 24

2.02

1.77

0.00030

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

3 of 16

2.2

1.44

0.0019

GO:0030332

Cyclin binding

2 of 6

2.45

1.01

0.0142

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

2 of 6

2.45

1.01

0.0142

GO:0004693

Cyclin-dependent protein serine/threonine kinase activity

2 of 9

2.27

0.94

0.0185

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008024

cyclin/CDK positive transcription elongation factor complex

4 of 4

2.92

4.16

2.13e-08

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

5 of 17

2.39

3.92

1.81e-08

GO:0008023

Transcription elongation factor complex

5 of 19

2.34

3.88

1.81e-08

GO:0070692

CTDK-1 complex

3 of 3

2.92

3.08

2.34e-06

GO:0061695

Transferase complex, transferring phosphorus-containing groups

6 of 124

1.61

2.36

3.63e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1146

Transcription elongation factor complex, and RNA polymerase II, core complex

10 of 39

2.33

8.19

1.21e-19

CL:1213

cyclin/CDK positive transcription elongation factor complex

5 of 5

2.92

5.5

5.75e-11

CL:1065

Mixed, incl. DNA-directed RNA polymerase complex, and Mediator complex

11 of 147

1.8

4.97

2.16e-17

CL:1154

RNA Polymerase II Transcription Elongation

5 of 23

2.26

3.78

1.90e-08

CL:1155

RNA polymerase II, core complex, and Transcription antitermination

4 of 14

2.38

3.22

5.49e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6796648

TP53 Regulates Transcription of DNA Repair Genes

9 of 41

2.26

6.95

9.66e-17

MAP-674695

RNA Polymerase II Pre-transcription Events

7 of 65

1.96

4.12

7.92e-11

MAP-3700989

Transcriptional Regulation by TP53

9 of 172

1.64

3.41

5.88e-12

MAP-212436

Generic Transcription Pathway

10 of 250

1.53

3.07

1.34e-12

MAP-113418

Formation of the Early Elongation Complex

4 of 32

2.02

2.44

8.51e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008023

Transcription elongation factor complex

8 of 25

2.43

6.98

1.71e-15

GOCC:0019908

Nuclear cyclin-dependent protein kinase holoenzyme complex

6 of 8

2.8

6.35

7.91e-13

GOCC:0008024

cyclin/CDK positive transcription elongation factor complex

5 of 6

2.84

5.35

9.36e-11

GOCC:0032044

DSIF complex

3 of 3

2.92

3.09

2.24e-06

GOCC:0061695

Transferase complex, transferring phosphorus-containing groups

7 of 139

1.63

2.78

7.32e-09

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

3 of 6

2.62

2.47

2.59e-05

KW-0251

Elongation factor

2 of 16

2.02

0.86

0.0240

KW-0804

Transcription

3 of 118

1.33

0.7

0.0275

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR043198

Cyclin/Cyclin-like subunit Ssn8

3 of 4

2.8

2.14

0.00012

IPR013763

Cyclin-like domain

3 of 8

2.5

1.91

0.00028

IPR006671

Cyclin, N-terminal

3 of 8

2.5

1.91

0.00028

IPR036915

Cyclin-like superfamily

3 of 12

2.32

1.81

0.00039

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

3 of 12

2.32

1.97

0.00018

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