LOC114663467 protein (Erpetoichthys calabaricus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

LOC114663467

Cytosolic non-specific dipeptidase-like. (533 aa)

Predicted Functional Partners:

ass1

0.886

abat

0.879

upb1

0.869

LOC114645040

0.863

gfpt2

0.863

aldh7a1

0.858

aldh4a1

0.858

aldh9a1

0.858

aldh16a1

0.858

LOC114668691

0.858

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC114645040	LOC114663467	ENSECRP00000023785	ENSECRP00000030854	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1-like.	Cytosolic non-specific dipeptidase-like.	0.863
LOC114645040	ass1	ENSECRP00000023785	ENSECRP00000021227	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1-like.	Argininosuccinate synthase 1.	0.888
LOC114663467	LOC114645040	ENSECRP00000030854	ENSECRP00000023785	Cytosolic non-specific dipeptidase-like.	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1-like.	0.863
LOC114663467	LOC114668691	ENSECRP00000030854	ENSECRP00000026907	Cytosolic non-specific dipeptidase-like.	Aldehyde dehydrogenase family 3 member B1-like.	0.858
LOC114663467	abat	ENSECRP00000030854	ENSECRP00000026913	Cytosolic non-specific dipeptidase-like.	4-aminobutyrate aminotransferase.	0.879
LOC114663467	aldh16a1	ENSECRP00000030854	ENSECRP00000014088	Cytosolic non-specific dipeptidase-like.	Aldehyde dehydrogenase 16 family member A1.	0.858
LOC114663467	aldh4a1	ENSECRP00000030854	ENSECRP00000010339	Cytosolic non-specific dipeptidase-like.	Aldehyde dehydrogenase 4 family member A1.	0.858
LOC114663467	aldh7a1	ENSECRP00000030854	ENSECRP00000007107	Cytosolic non-specific dipeptidase-like.	Aldehyde dehydrogenase 7 family member A1.	0.858
LOC114663467	aldh9a1	ENSECRP00000030854	ENSECRP00000011558	Cytosolic non-specific dipeptidase-like.	Aldehyde dehydrogenase 9 family member A1.	0.858
LOC114663467	ass1	ENSECRP00000030854	ENSECRP00000021227	Cytosolic non-specific dipeptidase-like.	Argininosuccinate synthase 1.	0.886
LOC114663467	gfpt2	ENSECRP00000030854	ENSECRP00000027631	Cytosolic non-specific dipeptidase-like.	Glutamine-fructose-6-phosphate transaminase 2.	0.863
LOC114663467	upb1	ENSECRP00000030854	ENSECRP00000026493	Cytosolic non-specific dipeptidase-like.	Beta-ureidopropionase 1.	0.869
LOC114668691	LOC114663467	ENSECRP00000026907	ENSECRP00000030854	Aldehyde dehydrogenase family 3 member B1-like.	Cytosolic non-specific dipeptidase-like.	0.858
LOC114668691	abat	ENSECRP00000026907	ENSECRP00000026913	Aldehyde dehydrogenase family 3 member B1-like.	4-aminobutyrate aminotransferase.	0.921
LOC114668691	aldh16a1	ENSECRP00000026907	ENSECRP00000014088	Aldehyde dehydrogenase family 3 member B1-like.	Aldehyde dehydrogenase 16 family member A1.	0.675
LOC114668691	aldh4a1	ENSECRP00000026907	ENSECRP00000010339	Aldehyde dehydrogenase family 3 member B1-like.	Aldehyde dehydrogenase 4 family member A1.	0.722
LOC114668691	aldh7a1	ENSECRP00000026907	ENSECRP00000007107	Aldehyde dehydrogenase family 3 member B1-like.	Aldehyde dehydrogenase 7 family member A1.	0.762
LOC114668691	aldh9a1	ENSECRP00000026907	ENSECRP00000011558	Aldehyde dehydrogenase family 3 member B1-like.	Aldehyde dehydrogenase 9 family member A1.	0.730
LOC114668691	ass1	ENSECRP00000026907	ENSECRP00000021227	Aldehyde dehydrogenase family 3 member B1-like.	Argininosuccinate synthase 1.	0.642
LOC114668691	upb1	ENSECRP00000026907	ENSECRP00000026493	Aldehyde dehydrogenase family 3 member B1-like.	Beta-ureidopropionase 1.	0.883

page 1 of 4

Network Stats

number of nodes:

9

number of edges:

15

average node degree:

3.33

avg. local clustering coefficient:

0.917

expected number of edges:

11

PPI enrichment p-value:

0.157

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060563

Neuroepithelial cell differentiation

3 of 9

3.07

2.79

2.69e-05

GO:0040036

Regulation of fibroblast growth factor receptor signaling pathway

3 of 31

2.53

2.05

0.00036

GO:0110148

Biomineralization

3 of 49

2.33

1.79

0.00090

GO:0030433

Ubiquitin-dependent ERAD pathway

3 of 72

2.17

1.61

0.0016

GO:0036035

Osteoclast development

2 of 8

2.94

1.53

0.0032

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005509

Calcium ion binding

7 of 822

1.48

2.17

3.93e-07

GO:0030145

Manganese ion binding

3 of 59

2.25

1.81

0.00076

GO:0051082

Unfolded protein binding

3 of 117

1.96

1.48

0.0022

GO:0016773

Phosphotransferase activity, alcohol group as acceptor

4 of 927

1.18

0.68

0.0288

GO:0016301

Kinase activity

4 of 1004

1.15

0.65

0.0343

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005788

Endoplasmic reticulum lumen

4 of 89

2.2

2.76

9.76e-06

GO:0005794

Golgi apparatus

5 of 1252

1.15

0.9

0.0037

GO:0005635

Nuclear envelope

3 of 296

1.55

0.89

0.0201

GO:0012505

Endomembrane system

8 of 3682

0.88

0.83

5.46e-05

GO:0005789

Endoplasmic reticulum membrane

4 of 958

1.17

0.72

0.0215

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:20628614

(2010) Promoter complexity and tissue-specific expression of stress response components in Mytilus galloprovincialis, a sessile marine invertebrate species.

3 of 4

3.42

3.44

2.52e-06

PMID:33199536

(2020) Mannose-Binding Lectin Possesses Agglutination Activity and Promotes Opsonophagocytosis of Macrophages with Calreticulin Interaction in an Early Vertebrate.

3 of 5

3.32

3.43

2.52e-06

PMID:28254621

(2017) Nutrigenomics and immune function in fish: new insights from omics technologies.

3 of 6

3.25

3.43

2.52e-06

PMID:24060503

(2014) Rainbow trout (Oncorhynchus mykiss) contain two calnexin genes which encode distinct proteins.

3 of 7

3.18

3.42

2.52e-06

PMID:35153391

(2022) Molecular cloning, sequence characterization, and expression analysis of C-type lectin (CTL) and ER-Golgi intermediate compartment 53-kDa protein (ERGIC-53) homologs from the freshwater prawn, Macrobrachium rosenbergii.

3 of 8

3.12

3.41

2.52e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:34412

Mixed, incl. FAM20, C-terminal, and Flavin-linked sulfhydryl oxidase activity

4 of 11

3.11

4.65

2.11e-08

CL:39427

Calreticulin, and Protein disulphide isomerase

3 of 6

3.25

3.62

1.22e-06

CL:34416

FAM20, C-terminal, and Flavin-linked sulfhydryl oxidase activity

3 of 6

3.25

3.62

1.22e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl04141

Protein processing in endoplasmic reticulum

3 of 179

1.77

1.38

0.0024

onl04145

Phagosome

3 of 210

1.7

1.35

0.0024

onl05168

Herpes simplex virus 1 infection

3 of 342

1.49

1.09

0.0054

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3000480

Scavenging by Class A Receptors

3 of 11

2.98

3.06

9.12e-06

MAP-901042

Calnexin/calreticulin cycle

3 of 33

2.5

2.6

3.85e-05

MAP-532668

N-glycan trimming in the ER and Calnexin/Calreticulin cycle

3 of 45

2.37

2.44

6.16e-05

MAP-8957275

Post-translational protein phosphorylation

4 of 168

1.92

2.27

3.85e-05

MAP-381426

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

4 of 199

1.85

2.15

4.99e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005788

Endoplasmic reticulum lumen

4 of 56

2.4

3.24

2.01e-06

GOCC:0012505

Endomembrane system

8 of 2410

1.07

1.21

2.27e-06

GOCC:0005794

Golgi apparatus

4 of 581

1.38

1.01

0.0062

GOCC:0005737

Cytoplasm

8 of 6894

0.61

0.44

0.0062

GOCC:0043231

Intracellular membrane-bounded organelle

8 of 7225

0.59

0.43

0.0062

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

3 of 26

2.61

2.81

1.82e-05

KW-0256

Endoplasmic reticulum

3 of 108

1.99

1.79

0.00055

KW-0106

Calcium

4 of 429

1.52

1.46

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06702

Golgi casein kinase, C-terminal, Fam20

4 of 6

3.37

5.42

1.34e-09

PF00262

Calreticulin family

3 of 5

3.32

3.68

1.00e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009169

Calreticulin

3 of 3

3.55

3.53

1.84e-06

IPR024869

FAM20

3 of 5

3.32

3.43

2.57e-06

IPR018124

Calreticulin/calnexin, conserved site

3 of 5

3.32

3.43

2.57e-06

IPR009581

FAM20, C-terminal

3 of 5

3.32

3.43

2.57e-06

IPR009033

Calreticulin/calnexin, P domain superfamily

3 of 5

3.32

3.43

2.57e-06

(more ...)

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