LOC114667240 protein (Erpetoichthys calabaricus)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:

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[Homology]

Score

LOC114667240

EGF-like repeat and discoidin I-like domain-containing protein 3. (518 aa)

Predicted Functional Partners:

ENSECRP00000009658

0.718

arid4a

0.714

arid4b

0.714

ENSECRP00000011256

0.699

mysm1

0.664

leo1

0.663

heph

0.639

mrpl3

0.636

met

0.611

ENSECRP00000022943

0.611

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECRP00000009658	LOC114667240	ENSECRP00000009658	ENSECRP00000031494	annotation not available	EGF-like repeat and discoidin I-like domain-containing protein 3.	0.718
ENSECRP00000011256	ENSECRP00000022943	ENSECRP00000011256	ENSECRP00000022943	annotation not available	annotation not available	0.901
ENSECRP00000011256	LOC114667240	ENSECRP00000011256	ENSECRP00000031494	annotation not available	EGF-like repeat and discoidin I-like domain-containing protein 3.	0.699
ENSECRP00000011256	met	ENSECRP00000011256	ENSECRP00000016154	annotation not available	MET proto-oncogene, receptor tyrosine kinase.	0.901
ENSECRP00000022943	ENSECRP00000011256	ENSECRP00000022943	ENSECRP00000011256	annotation not available	annotation not available	0.901
ENSECRP00000022943	LOC114667240	ENSECRP00000022943	ENSECRP00000031494	annotation not available	EGF-like repeat and discoidin I-like domain-containing protein 3.	0.611
ENSECRP00000022943	met	ENSECRP00000022943	ENSECRP00000016154	annotation not available	MET proto-oncogene, receptor tyrosine kinase.	0.875
LOC114667240	ENSECRP00000009658	ENSECRP00000031494	ENSECRP00000009658	EGF-like repeat and discoidin I-like domain-containing protein 3.	annotation not available	0.718
LOC114667240	ENSECRP00000011256	ENSECRP00000031494	ENSECRP00000011256	EGF-like repeat and discoidin I-like domain-containing protein 3.	annotation not available	0.699
LOC114667240	ENSECRP00000022943	ENSECRP00000031494	ENSECRP00000022943	EGF-like repeat and discoidin I-like domain-containing protein 3.	annotation not available	0.611
LOC114667240	arid4a	ENSECRP00000031494	ENSECRP00000023529	EGF-like repeat and discoidin I-like domain-containing protein 3.	AT-rich interaction domain 4A.	0.714
LOC114667240	arid4b	ENSECRP00000031494	ENSECRP00000025145	EGF-like repeat and discoidin I-like domain-containing protein 3.	AT-rich interaction domain 4B.	0.714
LOC114667240	heph	ENSECRP00000031494	ENSECRP00000014143	EGF-like repeat and discoidin I-like domain-containing protein 3.	Hephaestin.	0.639
LOC114667240	leo1	ENSECRP00000031494	ENSECRP00000026739	EGF-like repeat and discoidin I-like domain-containing protein 3.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.663
LOC114667240	met	ENSECRP00000031494	ENSECRP00000016154	EGF-like repeat and discoidin I-like domain-containing protein 3.	MET proto-oncogene, receptor tyrosine kinase.	0.611
LOC114667240	mrpl3	ENSECRP00000031494	ENSECRP00000024567	EGF-like repeat and discoidin I-like domain-containing protein 3.	Mitochondrial ribosomal protein L3.	0.636
LOC114667240	mysm1	ENSECRP00000031494	ENSECRP00000025794	EGF-like repeat and discoidin I-like domain-containing protein 3.	Myb like, SWIRM and MPN domains 1.	0.664
arid4a	LOC114667240	ENSECRP00000023529	ENSECRP00000031494	AT-rich interaction domain 4A.	EGF-like repeat and discoidin I-like domain-containing protein 3.	0.714
arid4a	arid4b	ENSECRP00000023529	ENSECRP00000025145	AT-rich interaction domain 4A.	AT-rich interaction domain 4B.	0.770
arid4a	mysm1	ENSECRP00000023529	ENSECRP00000025794	AT-rich interaction domain 4A.	Myb like, SWIRM and MPN domains 1.	0.936

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.851

expected number of edges:

11

PPI enrichment p-value:

5.48e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

5 of 44

2.28

3.21

4.21e-07

GO:0009636

Response to toxic substance

5 of 113

1.87

2.18

1.90e-05

GO:0098869

Cellular oxidant detoxification

4 of 54

2.1

2.12

6.20e-05

GO:0006805

Xenobiotic metabolic process

3 of 114

1.65

0.75

0.0315

GO:0046685

Response to arsenic-containing substance

2 of 18

2.27

0.75

0.0413

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016209

Antioxidant activity

4 of 56

2.08

2.18

4.20e-05

GO:0004364

Glutathione transferase activity

3 of 19

2.43

1.96

0.00021

GO:0015038

Glutathione disulfide oxidoreductase activity

2 of 3

3.05

1.58

0.0014

GO:0015036

Disulfide oxidoreductase activity

3 of 40

2.1

1.52

0.0012

GO:0016491

Oxidoreductase activity

8 of 805

1.23

1.45

5.00e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8432

Glutathione metabolism, and Epoxide hydrolase

9 of 27

2.75

9.93

1.40e-20

CL:8375

Glutathione metabolism, and Glutamate and glutamine metabolism

10 of 56

2.48

9.24

6.74e-21

CL:8434

Glutathione metabolism

8 of 22

2.79

8.91

3.59e-18

CL:8441

Glutathione peroxidase, and Glutathione S-transferase, C-terminal

7 of 12

2.99

8.46

1.08e-16

CL:8444

Glutathione S-transferase, C-terminal domain, and Thioredoxin peroxidase activity

4 of 5

3.13

4.52

5.51e-09

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

acs00480

Glutathione metabolism

8 of 44

2.49

7.73

5.76e-17

acs00980

Metabolism of xenobiotics by cytochrome P450

6 of 45

2.35

5.26

1.19e-11

acs00982

Drug metabolism - cytochrome P450

4 of 38

2.25

3.25

3.04e-07

acs00983

Drug metabolism - other enzymes

3 of 51

2.0

1.94

0.00012

acs01100

Metabolic pathways

9 of 1303

1.07

1.31

1.12e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-156590

Glutathione conjugation

4 of 33

2.31

2.66

7.08e-06

MAP-3299685

Detoxification of Reactive Oxygen Species

4 of 36

2.27

2.64

7.08e-06

MAP-211859

Biological oxidations

6 of 315

1.51

1.89

7.08e-06

MAP-156580

Phase II - Conjugation of compounds

4 of 103

1.82

1.8

0.00014

MAP-9711123

Cellular response to chemical stress

4 of 171

1.6

1.38

0.00078

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11007

0.23

0.22

0.0282

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14497

Glutathione S-transferase, C-terminal domain

2 of 9

2.57

0.79

0.0363

PF02798

Glutathione S-transferase, N-terminal domain

2 of 11

2.49

0.79

0.0363

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004046

Glutathione S-transferase, C-terminal

3 of 15

2.53

1.7

0.00072

IPR004045

Glutathione S-transferase, N-terminal

3 of 16

2.5

1.7

0.00072

IPR010987

Glutathione S-transferase, C-terminal-like

3 of 19

2.43

1.69

0.00072

IPR040079

Glutathione transferase family

3 of 21

2.38

1.68

0.00072

IPR036282

Glutathione S-transferase, C-terminal domain superfamily

3 of 27

2.27

1.66

0.00072

(more ...)

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