LOC114661637 protein (Erpetoichthys calabaricus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC114661637

Uncharacterized LOC114661637. (450 aa)

Predicted Functional Partners:

wdfy4

0.851

rbsn

0.825

eif3l

0.675

LOC114660664

0.674

cltc

0.598

ENSECRP00000025859

0.598

LOC114669138

0.598

clta

0.594

ENSECRP00000028697

0.594

ap2m1

0.568

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSECRP00000025859	ENSECRP00000028697	ENSECRP00000025859	ENSECRP00000028697	annotation not available	annotation not available	0.945
ENSECRP00000025859	LOC114660664	ENSECRP00000025859	ENSECRP00000013768	annotation not available	AP-2 complex subunit alpha-2-like.	0.907
ENSECRP00000025859	LOC114661637	ENSECRP00000025859	ENSECRP00000032451	annotation not available	Uncharacterized LOC114661637.	0.598
ENSECRP00000025859	ap2m1	ENSECRP00000025859	ENSECRP00000007144	annotation not available	Adaptor related protein complex 2 subunit mu 1.	0.800
ENSECRP00000025859	clta	ENSECRP00000025859	ENSECRP00000011235	annotation not available	Clathrin light chain A.	0.945
ENSECRP00000028697	ENSECRP00000025859	ENSECRP00000028697	ENSECRP00000025859	annotation not available	annotation not available	0.945
ENSECRP00000028697	LOC114660664	ENSECRP00000028697	ENSECRP00000013768	annotation not available	AP-2 complex subunit alpha-2-like.	0.978
ENSECRP00000028697	LOC114661637	ENSECRP00000028697	ENSECRP00000032451	annotation not available	Uncharacterized LOC114661637.	0.594
ENSECRP00000028697	LOC114669138	ENSECRP00000028697	ENSECRP00000031068	annotation not available	Clathrin heavy chain 1-like.	0.977
ENSECRP00000028697	ap2m1	ENSECRP00000028697	ENSECRP00000007144	annotation not available	Adaptor related protein complex 2 subunit mu 1.	0.902
ENSECRP00000028697	clta	ENSECRP00000028697	ENSECRP00000011235	annotation not available	Clathrin light chain A.	0.932
ENSECRP00000028697	cltc	ENSECRP00000028697	ENSECRP00000014982	annotation not available	Clathrin heavy chain.	0.977
LOC114660664	ENSECRP00000025859	ENSECRP00000013768	ENSECRP00000025859	AP-2 complex subunit alpha-2-like.	annotation not available	0.907
LOC114660664	ENSECRP00000028697	ENSECRP00000013768	ENSECRP00000028697	AP-2 complex subunit alpha-2-like.	annotation not available	0.978
LOC114660664	LOC114661637	ENSECRP00000013768	ENSECRP00000032451	AP-2 complex subunit alpha-2-like.	Uncharacterized LOC114661637.	0.674
LOC114660664	LOC114669138	ENSECRP00000013768	ENSECRP00000031068	AP-2 complex subunit alpha-2-like.	Clathrin heavy chain 1-like.	0.945
LOC114660664	ap2m1	ENSECRP00000013768	ENSECRP00000007144	AP-2 complex subunit alpha-2-like.	Adaptor related protein complex 2 subunit mu 1.	0.994
LOC114660664	clta	ENSECRP00000013768	ENSECRP00000011235	AP-2 complex subunit alpha-2-like.	Clathrin light chain A.	0.978
LOC114660664	cltc	ENSECRP00000013768	ENSECRP00000014982	AP-2 complex subunit alpha-2-like.	Clathrin heavy chain.	0.945
LOC114660664	wdfy4	ENSECRP00000013768	ENSECRP00000033138	AP-2 complex subunit alpha-2-like.	WDFY family member 4.	0.640

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.786

expected number of edges:

34

PPI enrichment p-value:

0.914

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

5 of 20

1.87

2.45

3.51e-06

GO:0010467

Gene expression

9 of 208

1.11

1.3

1.46e-06

GO:0009059

Macromolecule biosynthetic process

9 of 232

1.06

1.21

1.88e-06

GO:0031564

Transcription antitermination

2 of 4

2.17

0.98

0.0148

GO:0006353

DNA-templated transcription, termination

2 of 4

2.17

0.98

0.0148

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 5

2.25

1.7

0.00058

GO:0003735

Structural constituent of ribosome

4 of 55

1.33

1.0

0.0035

GO:0003723

RNA binding

5 of 96

1.19

0.98

0.0015

GO:0003676

Nucleic acid binding

9 of 370

0.86

0.78

0.00012

GO:0019843

rRNA binding

3 of 40

1.34

0.7

0.0297

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

3 of 6

2.17

1.8

0.00033

GO:0005840

Ribosome

4 of 59

1.3

1.06

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:74

Ribonucleoprotein, and Translation regulator activity

11 of 92

1.55

3.38

1.42e-14

CL:77

Ribosome, and Translation regulator activity

9 of 75

1.55

3.02

1.33e-11

CL:99

Ribosome

5 of 37

1.6

2.03

6.66e-06

CL:84

Ribosome

6 of 62

1.46

1.93

1.80e-06

CL:101

rRNA-binding

3 of 23

1.58

1.16

0.0030

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

con03020

RNA polymerase

3 of 4

2.34

2.07

0.00012

con03010

Ribosome

4 of 53

1.35

1.11

0.0015

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008023

Transcription elongation factor complex

2 of 2

2.47

0.99

0.0157

GOCC:0000428

DNA-directed RNA polymerase complex

4 of 63

1.27

0.77

0.0157

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 11

1.73

0.76

0.0320

GOCC:0005840

Ribosome

3 of 47

1.27

0.71

0.0238

GOCC:0032991

Protein-containing complex

8 of 534

0.65

0.43

0.0157

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 7

2.1

1.84

0.00025

KW-0689

Ribosomal protein

5 of 59

1.4

1.37

0.00023

KW-0889

Transcription antitermination

2 of 3

2.29

1.3

0.0037

KW-0806

Transcription termination

2 of 3

2.29

1.3

0.0037

KW-0548

Nucleotidyltransferase

3 of 33

1.43

1.0

0.0052

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00322

K homology RNA-binding domain

2 of 3

2.29

1.06

0.0110

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