ap3m1 protein (Erpetoichthys calabaricus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

ap3m1

Adaptor related protein complex 3 subunit mu 1. (466 aa)

Predicted Functional Partners:

ap3d1

0.997

ap3s2

0.991

ap3s1

0.989

LOC114660664

0.980

ap4e1

0.979

ap3b1

0.961

LOC114645052

0.961

LOC114667426

0.961

ap2s1

0.948

ap4m1

0.940

Your Current Organism:

Erpetoichthys calabaricus

NCBI taxonomy Id: 27687
Other names: Calamoichthys calabaricus, E. calabaricus, reedfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC114645052	LOC114660664	ENSECRP00000023859	ENSECRP00000013768	AP-3 complex subunit beta-2-like.	AP-2 complex subunit alpha-2-like.	0.913
LOC114645052	LOC114667426	ENSECRP00000023859	ENSECRP00000032475	AP-3 complex subunit beta-2-like.	AP-3 complex subunit beta-2.	0.917
LOC114645052	ap2s1	ENSECRP00000023859	ENSECRP00000000036	AP-3 complex subunit beta-2-like.	Adaptor related protein complex 2 subunit sigma 1.	0.731
LOC114645052	ap3d1	ENSECRP00000023859	ENSECRP00000024940	AP-3 complex subunit beta-2-like.	Adaptor related protein complex 3 subunit delta 1.	0.974
LOC114645052	ap3m1	ENSECRP00000023859	ENSECRP00000032477	AP-3 complex subunit beta-2-like.	Adaptor related protein complex 3 subunit mu 1.	0.961
LOC114645052	ap3s1	ENSECRP00000023859	ENSECRP00000008017	AP-3 complex subunit beta-2-like.	Adaptor related protein complex 3 subunit sigma 1.	0.953
LOC114645052	ap3s2	ENSECRP00000023859	ENSECRP00000027325	AP-3 complex subunit beta-2-like.	Adaptor related protein complex 3 subunit sigma 2.	0.953
LOC114645052	ap4e1	ENSECRP00000023859	ENSECRP00000026581	AP-3 complex subunit beta-2-like.	Adaptor related protein complex 4 subunit epsilon 1.	0.916
LOC114645052	ap4m1	ENSECRP00000023859	ENSECRP00000013973	AP-3 complex subunit beta-2-like.	Adaptor related protein complex 4 subunit mu 1.	0.774
LOC114660664	LOC114645052	ENSECRP00000013768	ENSECRP00000023859	AP-2 complex subunit alpha-2-like.	AP-3 complex subunit beta-2-like.	0.913
LOC114660664	LOC114667426	ENSECRP00000013768	ENSECRP00000032475	AP-2 complex subunit alpha-2-like.	AP-3 complex subunit beta-2.	0.913
LOC114660664	ap2s1	ENSECRP00000013768	ENSECRP00000000036	AP-2 complex subunit alpha-2-like.	Adaptor related protein complex 2 subunit sigma 1.	0.999
LOC114660664	ap3b1	ENSECRP00000013768	ENSECRP00000007521	AP-2 complex subunit alpha-2-like.	Adaptor related protein complex 3 subunit beta 1.	0.913
LOC114660664	ap3d1	ENSECRP00000013768	ENSECRP00000024940	AP-2 complex subunit alpha-2-like.	Adaptor related protein complex 3 subunit delta 1.	0.963
LOC114660664	ap3m1	ENSECRP00000013768	ENSECRP00000032477	AP-2 complex subunit alpha-2-like.	Adaptor related protein complex 3 subunit mu 1.	0.980
LOC114660664	ap3s1	ENSECRP00000013768	ENSECRP00000008017	AP-2 complex subunit alpha-2-like.	Adaptor related protein complex 3 subunit sigma 1.	0.977
LOC114660664	ap3s2	ENSECRP00000013768	ENSECRP00000027325	AP-2 complex subunit alpha-2-like.	Adaptor related protein complex 3 subunit sigma 2.	0.977
LOC114660664	ap4e1	ENSECRP00000013768	ENSECRP00000026581	AP-2 complex subunit alpha-2-like.	Adaptor related protein complex 4 subunit epsilon 1.	0.945
LOC114660664	ap4m1	ENSECRP00000013768	ENSECRP00000013973	AP-2 complex subunit alpha-2-like.	Adaptor related protein complex 4 subunit mu 1.	0.976
LOC114667426	LOC114645052	ENSECRP00000032475	ENSECRP00000023859	AP-3 complex subunit beta-2.	AP-3 complex subunit beta-2-like.	0.917

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.859

expected number of edges:

10

PPI enrichment p-value:

0.105

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032957

Inositol trisphosphate metabolic process

4 of 5

3.24

4.19

2.40e-08

GO:0070266

Necroptotic process

4 of 13

2.83

3.59

2.27e-07

GO:0006066

Alcohol metabolic process

5 of 291

1.58

1.61

0.00014

GO:0052746

Inositol phosphorylation

2 of 3

3.16

1.54

0.0017

GO:0032958

Inositol phosphate biosynthetic process

2 of 14

2.5

0.97

0.0167

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000825

Inositol tetrakisphosphate 6-kinase activity

4 of 4

3.34

4.61

4.39e-09

GO:0051766

Inositol trisphosphate kinase activity

4 of 9

2.99

4.26

1.49e-08

GO:0003993

Acid phosphatase activity

3 of 7

2.97

2.88

5.66e-06

GO:0102732

myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

GO:0052726

inositol-1,3,4-trisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30075

Acid phosphatase activity, and Alkaline phosphatase activity

6 of 14

2.97

6.68

3.23e-13

CL:30076

Acid phosphatase activity, and Phosphodiesterase I activity

4 of 7

3.1

4.32

1.27e-08

CL:38050

Inositol trisphosphate kinase activity, and Inositol tetrakisphosphate phosphatase activity

4 of 17

2.71

3.62

1.72e-07

CL:38074

Inositol phosphorylation, and Inositol tetrakisphosphate 5-kinase activity

3 of 5

3.12

2.98

3.89e-06

CL:30089

Alkaline phosphatase activity, and Acid phosphatase activity

2 of 7

2.8

1.41

0.0028

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00730

Thiamine metabolism

4 of 21

2.62

3.84

5.24e-08

map00740

Riboflavin metabolism

3 of 19

2.54

2.8

5.30e-06

map00562

Inositol phosphate metabolism

5 of 169

1.81

2.66

5.39e-07

map04070

Phosphatidylinositol signaling system

4 of 181

1.68

1.89

4.16e-05

map01100

Metabolic pathways

11 of 3242

0.87

0.96

5.24e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

5 of 70

2.19

3.28

1.94e-07

MAP-196819

Vitamin B1 (thiamin) metabolism

2 of 5

2.94

1.47

0.0022

MAP-1855191

Synthesis of IPs in the nucleus

2 of 7

2.8

1.41

0.0028

MAP-1855167

Synthesis of pyrophosphates in the cytosol

2 of 10

2.64

1.3

0.0042

MAP-196849

Metabolism of water-soluble vitamins and cofactors

3 of 192

1.53

0.79

0.0228

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00149

Calcineurin-like phosphoesterase

3 of 14

2.67

2.15

0.00011

PF05770

Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain

2 of 2

3.34

1.6

0.0013

PF03770

Inositol polyphosphate kinase

2 of 9

2.69

1.15

0.0081

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