node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PEPE_0385 | PEPE_1546 | PEPE_0385 | PEPE_1546 | Guanylate kinase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.914 |
PEPE_0385 | apt | PEPE_0385 | PEPE_1129 | Guanylate kinase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.944 |
PEPE_0385 | gmk | PEPE_0385 | PEPE_0825 | Guanylate kinase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.922 |
PEPE_0385 | guaA | PEPE_0385 | PEPE_0412 | Guanylate kinase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.951 |
PEPE_0385 | guaC | PEPE_0385 | PEPE_0595 | Guanylate kinase. | IMP dehydrogenase/GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.913 |
PEPE_0385 | xpt | PEPE_0385 | PEPE_1374 | Guanylate kinase. | Adenine/guanine phosphoribosyltransferase related PRPP-binding protein; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.943 |
PEPE_1246 | PEPE_1719 | PEPE_1246 | PEPE_1719 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.684 |
PEPE_1246 | apt | PEPE_1246 | PEPE_1129 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.962 |
PEPE_1246 | guaA | PEPE_1246 | PEPE_0412 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.910 |
PEPE_1246 | guaC | PEPE_1246 | PEPE_0595 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | IMP dehydrogenase/GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.882 |
PEPE_1246 | purA | PEPE_1246 | PEPE_1247 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.998 |
PEPE_1246 | purH | PEPE_1246 | PEPE_1458 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | IMP cyclohydrolase. | 0.992 |
PEPE_1246 | xpt | PEPE_1246 | PEPE_1374 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenine/guanine phosphoribosyltransferase related PRPP-binding protein; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.709 |
PEPE_1546 | PEPE_0385 | PEPE_1546 | PEPE_0385 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanylate kinase. | 0.914 |
PEPE_1546 | PEPE_1719 | PEPE_1546 | PEPE_1719 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.918 |
PEPE_1546 | apt | PEPE_1546 | PEPE_1129 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.939 |
PEPE_1546 | gmk | PEPE_1546 | PEPE_0825 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.914 |
PEPE_1546 | guaA | PEPE_1546 | PEPE_0412 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.975 |
PEPE_1546 | guaC | PEPE_1546 | PEPE_0595 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | IMP dehydrogenase/GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.918 |
PEPE_1546 | purA | PEPE_1546 | PEPE_1247 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.946 |